Abstract

The Research Support Core will be responsible for the coordination of all aspects of dispersing human and mouse tissues for the proposed program project and for coordinating use of the confocal facilities. The Research Core will be composed of the Core Director, James Melvin, D.D.S., PhD., Associate Director, Trevor Shuttleworth, Ph.D., and a Technical Associate, Ms. Linda Richardson.
The Specific Aims of the core will be to: 1. Prepare all human parotid tissues and distribute these tissues to appropriate members of the Program Project. 2. Prepare and distribute all mouse parotid tissues to appropriate members of the Program Project. 3. Monitoring and maintaining the status of the different mouse knockout lines. 4. Coordinate the histological analysis of the human and mouse parotid tissues in collaboration with Dr. Art Hand at the University of Connecticut. 5. Ensure appropriate access to the two confocal microscope facilities for all members of the Program Project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Program Projects (P01)
Project #
5P01DE013539-02
Application #
6438189
Study Section
Special Emphasis Panel (ZDE1)
Project Start
2000-04-01
Project End
2005-03-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2001
Total Cost
$221,831
Indirect Cost

  Institution

Name
University of Rochester
Department
Type
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Reyes, Juan Pablo; Perez-Cornejo, Patricia; Hernandez-Carballo, Carmen Y et al. (2008) Na+ modulates anion permeation and block of P2X7 receptors from mouse parotid glands. J Membr Biol 223:73-85
Romanenko, Victor G; Nakamoto, Tetsuji; Srivastava, Alaka et al. (2007) Regulation of membrane potential and fluid secretion by Ca2+-activated K+ channels in mouse submandibular glands. J Physiol 581:801-17
Romanenko, Victor; Nakamoto, Tetsuji; Srivastava, Alaka et al. (2006) Molecular identification and physiological roles of parotid acinar cell maxi-K channels. J Biol Chem 281:27964-72
Thompson, Jill; Begenisich, Ted (2006) Membrane-delimited inhibition of maxi-K channel activity by the intermediate conductance Ca2+-activated K channel. J Gen Physiol 127:159-69
Mignen, Olivier; Thompson, Jill L; Yule, David I et al. (2005) Agonist activation of arachidonate-regulated Ca2+-selective (ARC) channels in murine parotid and pancreatic acinar cells. J Physiol 564:791-801
Hartzell, Criss; Putzier, Ilva; Arreola, Jorge (2005) Calcium-activated chloride channels. Annu Rev Physiol 67:719-58
Melvin, James E; Yule, David; Shuttleworth, Trevor et al. (2005) Regulation of fluid and electrolyte secretion in salivary gland acinar cells. Annu Rev Physiol 67:445-69
Tsaneva-Atanasova, K; Yule, D I; Sneyd, J (2005) Calcium oscillations in a triplet of pancreatic acinar cells. Biophys J 88:1535-51
Straub, Stephen V; Wagner 2nd, Larry E; Bruce, Jason I E et al. (2004) Modulation of cytosolic calcium signaling by protein kinase A-mediated phosphorylation of inositol 1,4,5-trisphosphate receptors. Biol Res 37:593-602
Begenisich, Ted; Nakamoto, Tesuji; Ovitt, Catherine E et al. (2004) Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4. J Biol Chem 279:47681-7

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