Abstract

As a natural progression of their work investigators of the Program project Grant will utilize transgenic or gene disrupted (knockout) mice to determine the impact of over expression or lack of expression of specific genes within the kidney. The core facility (Core B) will provide transgenic and knockout mice to the Principal Investigators of the different projects. The core will also prepare Promoter-Reporter constructs and provide Investigators of the different projects. The core will also prepare Promoter-Reporter constructs and provide histological analyses of kidney tissue, including morphology, macrophage infiltration, NF-kappaB isotypes, smooth muscle actin expression etc. The core laboratory (Core B) will be utilized by all of the investigator participating in this Program Project Grant.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
2P01DK009976-34
Application #
6104975
Study Section
Project Start
1999-03-01
Project End
1999-12-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
34
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Barnes-Jewish Hospital
Department
Type
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63110

  Publications

Slatopolsky, Eduardo (2011) The intact nephron hypothesis: the concept and its implications for phosphate management in CKD-related mineral and bone disorder. Kidney Int Suppl :S3-8
Morrissey, Jeremiah; Hruska, Keith; Guo, Guangjie et al. (2002) Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function. J Am Soc Nephrol 13 Suppl 1:S14-21
Hruska, Keith A (2002) Treatment of chronic tubulointerstitial disease: a new concept. Kidney Int 61:1911-22
Morrissey, Jeremiah; Guo, Guangjie; Moridaira, Kazuaki et al. (2002) Transforming growth factor-beta induces renal epithelial jagged-1 expression in fibrotic disease. J Am Soc Nephrol 13:1499-508
Hruska, K A; Guo, G; Wozniak, M et al. (2000) Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction. Am J Physiol Renal Physiol 279:F130-43
Klahr, S (1999) Mechanisms of progression of chronic renal damage. J Nephrol 12 Suppl 2:S53-62
Hemken, P; Guo, X L; Wang, Z Q et al. (1992) Immunologic evidence that vacuolar H+ ATPases with heterogeneous forms of Mr = 31,000 subunit have different membrane distributions in mammalian kidney. J Biol Chem 267:9948-57
Reyes, A A; Robertson, G; Jenden, D J et al. (1992) Subdiaphragmatic vagotomy in rats induces systemic hypertension and sodium retention. Miner Electrolyte Metab 18:375-81
Portilla, D; Mordhorst, M; Bertrand, W et al. (1988) Protein kinase C modulates phospholipase C and increases arachidonic acid release in bradykinin stimulated MDCK cells. Biochem Biophys Res Commun 153:454-62