Abstract

This is an application for continuation of a program project grant. The basic overall objectives have been to: (a) Analyze and isolate the clinical problems involved in organ transplantation and precisely document clinical-laboratory correlations. (b) Organize clinical trials based on available data to solve clinical problems. (c) Generate experimental solutions to these problems which can ultimately be applied to the clinical problem. Within these objectives, there are four essential aims in clinical transplantation under which all our projects have been organized.
Aim 1 : To Prevent Organ Destruction by host. This includes problems of tissue typing, matching, and immunosuppression related to rejection as well as problems of recurrent disease.
Aim 2 : To Counteract Infection.
Aim 3 : To Maximize Rehabilitation.
Aim 4 : To Maintain Patient and Organ in Optimal Condition Prior to and During Transplantation. This includes problems of hemodialysis, organ retrieval, and storage.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK013083-24
Application #
3095135
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1977-09-01
Project End
1992-08-31
Budget Start
1991-09-01
Budget End
1992-08-31
Support Year
24
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Berglund, Danielle M; Zhang, Lei; Matas, Arthur J et al. (2018) Measured Glomerular Filtration Rate After Kidney Donation: No Evidence of Accelerated Decay. Transplantation 102:1756-1761
Matas, Arthur J; Vock, David M; Ibrahim, Hassan N (2018) GFR ?25 years postdonation in living kidney donors with (vs. without) a first-degree relative with ESRD. Am J Transplant 18:625-631
Sanchez, Otto A; Ferrara, Laine K; Rein, Sarah et al. (2018) Hypertension after kidney donation: Incidence, predictors, and correlates. Am J Transplant 18:2534-2543
Kizilbash, Sarah J; Rheault, Michelle N; Bangdiwala, Ananta et al. (2017) Infection rates in tacrolimus versus cyclosporine-treated pediatric kidney transplant recipients on a rapid discontinuation of prednisone protocol: 1-year analysis. Pediatr Transplant 21:
Verghese, P S; Schmeling, D O; Filtz, E A et al. (2017) The impact of recipient BKV shedding before transplant on BKV viruria, DNAemia, and nephropathy post-transplant: A prospective study. Pediatr Transplant 21:
Serrano, Oscar Kenneth; Kandaswamy, Raja; Gillingham, Kristen et al. (2017) Rapid Discontinuation of Prednisone in Kidney Transplant Recipients: 15-Year Outcomes From the University of Minnesota. Transplantation 101:2590-2598
Ibrahim, H N; Berglund, D M; Jackson, S et al. (2017) Renal Consequences of Diabetes After Kidney Donation. Am J Transplant 17:3141-3148
Gross, Cynthia R; Reilly-Spong, Maryanne; Park, Taehwan et al. (2017) Telephone-adapted Mindfulness-based Stress Reduction (tMBSR) for patients awaiting kidney transplantation. Contemp Clin Trials 57:37-43
Ibrahim, Hassan N; Foley, Robert N; Reule, Scott A et al. (2016) Renal Function Profile in White Kidney Donors: The First 4 Decades. J Am Soc Nephrol 27:2885-93
Verghese, Priya; Gillingham, Kristen; Matas, Arthur et al. (2016) Post-transplant blood transfusions and pediatric renal allograft outcomes. Pediatr Transplant 20:939-945

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