The research core laboratory, Core B, directed by Dr. Juan Capasso, is a resource facility located within the Division of Renal Diseases and Hypertension at the University of Colorado Health Sciences Center. it is comprised of laboratories set up as a core facility for all the investigators of the program project. The research core provides access to the necessary general equipment and supplies shared by all of the investigators of the program project. Specifically, the Core B includes a tissue culture facility/laboratory (Milli-Q water system, CO2 incubators, laminar flow hoods, microscopes, cryostorage, supplies/reagents), large equipment rooms (spectrophotometers, refrigerators, freezers, pH meters, centrifuges, film developer, PCR, analyzers and electrophoresis equipment), a radioactivity laboratory (beta and gamma counters and radioactive waste disposal containers), a dishwashing room (drying oven, autoclave etc), and an animal surgery laboratory (dissecting scopes, surgical instruments and supplies, scales, pumps, metabolic cages, restraining devices, incubator, small and micro hematocrit centrifuges, heated surgical tables, small animal blood flow meter/renal blood flow and blood pressure system, tail cuff blood pressure analyzer). In addition, an inventory of standard chemicals/reagents, glassware and expendable supplies will be maintained for use by all the investigators. This core will also support the service contracts and repair of these facilities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK019928-30
Application #
7667922
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
30
Fiscal Year
2008
Total Cost
$121,371
Indirect Cost
Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Li, Chunling; Wang, Weidong; Rivard, Christopher J et al. (2011) Molecular mechanisms of angiotensin II stimulation on aquaporin-2 expression and trafficking. Am J Physiol Renal Physiol 300:F1255-61
Andres-Hernando, Ana; Lanaspa, Miguel A; Li, Nanxing et al. (2010) Effects of 2-bromoethanamine on TonEBP expression and its possible role in induction of renal papillary necrosis in mice. Toxicol Sci 118:510-20
Furgeson, Seth B; Simpson, Peter A; Park, Insun et al. (2010) Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation. Cardiovasc Res 86:274-82
Wang, Weidong; Li, Chunling; Summer, Sandra et al. (2010) Interaction between vasopressin and angiotensin II in vivo and in vitro: effect on aquaporins and urine concentration. Am J Physiol Renal Physiol 299:F577-84
Schrier, Robert W (2010) Systemic arterial vasodilation, vasopressin, and vasopressinase in pregnancy. J Am Soc Nephrol 21:570-2
Lanaspa, Miguel A; Andres-Hernando, Ana; Rivard, Christopher J et al. (2009) ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells. J Biol Chem 284:19974-81
Schrier, Robert W (2009) Interactions between angiotensin II and arginine vasopressin in water homeostasis. Kidney Int 76:137-9
Berl, Tomas (2009) How do kidney cells adapt to survive in hypertonic inner medulla? Trans Am Clin Climatol Assoc 120:389-401
Bansal, Shweta; Lindenfeld, JoAnn; Schrier, Robert W (2009) Sodium retention in heart failure and cirrhosis: potential role of natriuretic doses of mineralocorticoid antagonist? Circ Heart Fail 2:370-6
Schrier, Robert W; Masoumi, Amirali; Elhassan, Elwaleed (2009) Role of vasopressin and vasopressin receptor antagonists in type I cardiorenal syndrome. Blood Purif 27:28-32

Showing the most recent 10 out of 153 publications