The ultimate goal of this project is to develop a rational treatment program for urolithiasis in which the treatment is selected on the basis of its appropriate physicochemical effects on stone formation in urine, the correction of the underlying physiologic derangements, and minimal potential complications. This goal will be pursued by four multidisciplinary approaches. (1) Biochemical and physiocochemical. Studies will be concerned with the characterization of promoters and inhibitors of crystallization in urine and in stones. (2) Physiological. These studies will consider the mode of intestinal absorption of stone-forming substances using triple-lumen technique, role of vitamin D in urolithiasis, and the pathophysiology of hypercalciurias. (3) The mode of action of various therapeutic modalities for urolithiasis. These include allopurinol, diphenylhydantoin and sodium cellulose phosphate. Both physiocochemical and physiological action of modalities will be sought. (4) Diagnosis and therapy of nephrolithiasis. A reliable ambulatory protocol for the diagnosis of various causes of stones will be developed. Working criteria for optimum therapy will be formulated whereby a specific treatment is chosen for a particular cause of stones, on the basis of its ability to """"""""correct"""""""" physicochemical and physiological derangements. The rational therapy of urolithiasis will have been achieved if during long-term clinical trials, the particular optimum therapy is shown to prevent stone formation, exert appropriate physicochemical effects in urine, correct underlying physiological disorders and cause minimal or tolerable side-effects.
| Xu, Li Hao Richie; Maalouf, Naim M (2017) Effect of acute hyperinsulinemia on magnesium homeostasis in humans. Diabetes Metab Res Rev 33: |
| Xu, Li Hao Richie; Adams-Huet, Beverley; Poindexter, John R et al. (2017) Temporal Changes in Kidney Stone Composition and in Risk Factors Predisposing to Stone Formation. J Urol 197:1465-1471 |
| Sakhaee, Khashayar; Poindexter, John; Aguirre, Crystal (2016) The effects of bariatric surgery on bone and nephrolithiasis. Bone 84:1-8 |
| Hu, Ming Chang; Shi, Mingjun; Cho, Han Jun et al. (2015) Klotho and phosphate are modulators of pathologic uremic cardiac remodeling. J Am Soc Nephrol 26:1290-302 |
| Hajibeigi, Asghar; Dioum, Elhadji M; Guo, Jianfei et al. (2015) Identification of novel regulatory NFAT and TFII-I binding elements in the calbindin-D28k promoter in response to serum deprivation. Biochem Biophys Res Commun 465:414-420 |
| Yoon, Vivienne; Adams-Huet, Beverley; Sakhaee, Khashayar et al. (2013) Hyperinsulinemia and urinary calcium excretion in calcium stone formers with idiopathic hypercalciuria. J Clin Endocrinol Metab 98:2589-94 |
| Capolongo, Giovanna; Abul-Ezz, Sameh; Moe, Orson W et al. (2012) Subclinical celiac disease and crystal-induced kidney disease following kidney transplant. Am J Kidney Dis 60:662-7 |
| Cameron, MaryAnn; Maalouf, Naim M; Poindexter, John et al. (2012) The diurnal variation in urine acidification differs between normal individuals and uric acid stone formers. Kidney Int 81:1123-30 |
| Sakhaee, Khashayar; Capolongo, Giovanna; Maalouf, Naim M et al. (2012) Metabolic syndrome and the risk of calcium stones. Nephrol Dial Transplant 27:3201-9 |
| Maalouf, Naim M; Langston, Joshua P; Van Ness, Paul C et al. (2011) Nephrolithiasis in topiramate users. Urol Res 39:303-7 |
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