The overall goal of this long-standing program project (in its 16th year) is to achieve a total control of nephrolithiasis, by pursuing pathophysiological elucidation using metabolic and molecular approaches, and by formulating innovative treatments that are safe and effective. In Component I, pathogenetic role of vitamin D for increased Ca absorption in absorptive hypercalciuria will be sought by examining monocytes, skin fibroblasts and osteoblasts for abnormality in vitamin D receptor gene and function. Moreover, response to a new drug (UroPhos-K or slow release neutral potassium phosphate) will be elucidated in order to determine whether this treatment would provide a complete or partial correction of absorptive hypercalciuria. In Component II, Na/citrate co-transporter gene will be cloned in order to determine molecular basis for renal hypocitraturia, a condition characterized by defective citrate excretion in the absence of RTA or bowel disease. Component III will be concerned with the laboratory and clinical aspects of extracorporeal shock wave lithotripsy (ESWL). Etiological role of free radicals in renal tissue damage post-lithotripsy will be examined, and the work on computer modelling and physics of lithotripsy will be continued. Clinically, a randomized trial with potassium-magnesium citrate (K-Mag) will be conducted during peri-ESWL period, in order to determine if this treatment would avert residual calculi. Component IV will seek new, improved treatments for nephrolithiasis. They include UroPhos-K for absorptive hypercalciuria, K-Mag in hypocitraturia, bucillamine (a dithiol compound) in cystinuria, and aminobutylidine diphosphonate in immobilization. Careful randomized metabolic studies, as well as long-term trials, are plan d.
| Xu, Li Hao Richie; Maalouf, Naim M (2017) Effect of acute hyperinsulinemia on magnesium homeostasis in humans. Diabetes Metab Res Rev 33: |
| Xu, Li Hao Richie; Adams-Huet, Beverley; Poindexter, John R et al. (2017) Temporal Changes in Kidney Stone Composition and in Risk Factors Predisposing to Stone Formation. J Urol 197:1465-1471 |
| Sakhaee, Khashayar; Poindexter, John; Aguirre, Crystal (2016) The effects of bariatric surgery on bone and nephrolithiasis. Bone 84:1-8 |
| Hu, Ming Chang; Shi, Mingjun; Cho, Han Jun et al. (2015) Klotho and phosphate are modulators of pathologic uremic cardiac remodeling. J Am Soc Nephrol 26:1290-302 |
| Hajibeigi, Asghar; Dioum, Elhadji M; Guo, Jianfei et al. (2015) Identification of novel regulatory NFAT and TFII-I binding elements in the calbindin-D28k promoter in response to serum deprivation. Biochem Biophys Res Commun 465:414-420 |
| Yoon, Vivienne; Adams-Huet, Beverley; Sakhaee, Khashayar et al. (2013) Hyperinsulinemia and urinary calcium excretion in calcium stone formers with idiopathic hypercalciuria. J Clin Endocrinol Metab 98:2589-94 |
| Capolongo, Giovanna; Abul-Ezz, Sameh; Moe, Orson W et al. (2012) Subclinical celiac disease and crystal-induced kidney disease following kidney transplant. Am J Kidney Dis 60:662-7 |
| Cameron, MaryAnn; Maalouf, Naim M; Poindexter, John et al. (2012) The diurnal variation in urine acidification differs between normal individuals and uric acid stone formers. Kidney Int 81:1123-30 |
| Sakhaee, Khashayar; Capolongo, Giovanna; Maalouf, Naim M et al. (2012) Metabolic syndrome and the risk of calcium stones. Nephrol Dial Transplant 27:3201-9 |
| Nguyen, Trang Q; Maalouf, Naim M; Sakhaee, Khashayar et al. (2011) Comparison of insulin action on glucose versus potassium uptake in humans. Clin J Am Soc Nephrol 6:1533-9 |
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