Abstract

During the coming year, we will do the following: 1. Continue studying the adsorption of polymers on COM, with emphasis on theoretical analysis of RNA, and data generation for polyglutamic acid and pentosan sulfate (zeta potential, particle size distribution, solution depletion and inhibition of growth and nucleation). 2. Proposed with the development of a multiwell nucleator to address the stochastic character of nucleation. 3. Do an electron microscopic study of the morphology of nascent COM precipitates. 4. Continue studies of the encrustability of chemically modified urinary catheter surfaces. 5. Continue studies of the physical aspects of extracorporeal shock wave lithotripsy. 6. Continue to study lamination structure during calcium oxalate stone growth induced on plastic foreign bodies. Alterations in urine pH and gender will be studied to determine their influence upon stone structure. 7. Determine the effect of sub-lethal cell injury upon heterogenous calcium oxalate crystal formation in the urine.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK020586-10
Application #
3095232
Study Section
(SRC)
Project Start
1977-09-01
Project End
1987-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
10
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Florida
Department
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611

  Publications

Thamilselvan, S; Hackett, R L; Khan, S R (1999) Cells of proximal and distal tubular origin respond differently to challenges of oxalate and calcium oxalate crystals. J Am Soc Nephrol 10 Suppl 14:S452-6
Iida, S; Peck, A B; Johnson-Tardieu, J et al. (1999) Temporal changes in mRNA expression for bikunin in the kidneys of rats during calcium oxalate nephrolithiasis. J Am Soc Nephrol 10:986-96
Sidhu, H; Holmes, R P; Allison, M J et al. (1999) Direct quantification of the enteric bacterium Oxalobacter formigenes in human fecal samples by quantitative competitive-template PCR. J Clin Microbiol 37:1503-9
Atmani, F; Khan, S R (1999) Role of inter-alpha-inhibitor and its related proteins in urolithiasis. Purification of an inter-alpha-inhibitor related protein from the bovine kidney. Urol Res 27:57-61
Atmani, F; Glenton, P A; Khan, S R (1999) Role of inter-alpha-inhibitor and its related proteins in experimentally induced calcium oxalate urolithiasis. Localization of proteins and expression of bikunin gene in the rat kidney. Urol Res 27:63-7
Sidhu, H; Schmidt, M E; Cornelius, J G et al. (1999) Direct correlation between hyperoxaluria/oxalate stone disease and the absence of the gastrointestinal tract-dwelling bacterium Oxalobacter formigenes: possible prevention by gut recolonization or enzyme replacement therapy. J Am Soc Nephrol 10 Suppl 14:S334-40
Thamilselvan, S; Khan, S R (1998) Oxalate and calcium oxalate crystals are injurious to renal epithelial cells: results of in vivo and in vitro studies. J Nephrol 11 Suppl 1:66-9
Atmani, F; Glenton, P A; Khan, S R (1998) Identification of proteins extracted from calcium oxalate and calcium phosphate crystals induced in the urine of healthy and stone forming subjects. Urol Res 26:201-7
Khan, S R (1997) Animal models of kidney stone formation: an analysis. World J Urol 15:236-43
Gokhale, J A; Glenton, P A; Khan, S R (1997) Biochemical and quantitative analysis of Tamm Horsfall protein in rats. Urol Res 25:347-54

Showing the most recent 10 out of 51 publications