Shigella is a major cause of diarrhea, dysentery, and morbidity worldwide. S. flexneri is also a CDC/NIAID Category B priority pathogen that causes disease by invading and spreading through the colonic mucosa. The goal of this proposal is to understand the molecular mechanisms by which S. flexneri invades the colonic epithelium and subsequently triggers/controls the directed movement of PMN across the epithelial surface so that novel targets for therapeutic intervention in inflammatory Shigella infection can be identified.
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