Abstract

The specific aim of this core is to provide essential imaging support for projects in the grant. In addition to continuing the use of ultrasound to diagnose autosomal dominant polycystic kidney disease (ADPKD), ultrasound will be used to assess the natural history of ADPKD by longitudinally imaging patients. Liver and kidney volume, percentage of normal parenchyma, and percentage of cyst involvement will be measured. Selected pregnant patients will be imaged to determine earliest manifestation of ADPKD in utero and the fetuses will be evaluated for renal size, echogenicity, and presence or absence of renal cysts. Growth of the fetal liver and fetal kidneys will also be monitored. Extrarenal manifestations of the disease will be evaluated. Intracranial aneurysms will be evaluated primarily by dynamic computed tomography with angiography for confirmation of suspicious lesions. Certain ADPKD patients will be evaluated for diverticula by air-contrast barium enema.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK034039-14
Application #
6105262
Study Section
Project Start
1999-04-01
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
14
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Perrone, Ronald D; Mouksassi, Mohamad-Samer; Romero, Klaus et al. (2017) Total Kidney Volume Is a Prognostic Biomarker of Renal Function Decline and Progression to End-Stage Renal Disease in Patients With Autosomal Dominant Polycystic Kidney Disease. Kidney Int Rep 2:442-450
Perrone, Ronald D; Mouksassi, Mohamad-Samer; Romero, Klaus et al. (2017) A Drug Development Tool for Trial Enrichment in Patients With Autosomal Dominant Polycystic Kidney Disease. Kidney Int Rep 2:451-460
Nowak, Kristen L; Cadnapaphornchai, Melissa A; Chonchol, Michel B et al. (2016) Long-Term Outcomes in Patients with Very-Early Onset Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol 44:171-8
Schrier, Robert W; Abebe, Kaleab Z; Perrone, Ronald D et al. (2014) Blood pressure in early autosomal dominant polycystic kidney disease. N Engl J Med 371:2255-66
Helal, Imed; Reed, Berenice; Mettler, Pamela et al. (2012) Prevalence of cardiovascular events in patients with autosomal dominant polycystic kidney disease. Am J Nephrol 36:362-70
Reed, Berenice Y; Masoumi, Amirali; Elhassan, Elwaleed et al. (2011) Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney disease. Kidney Int 79:128-34
Helal, Imed; Reed, Berenice; McFann, Kim et al. (2011) Glomerular hyperfiltration and renal progression in children with autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol 6:2439-43
Reed, Berenice; McFann, Kim; Kimberling, William J et al. (2008) Presence of de novo mutations in autosomal dominant polycystic kidney disease patients without family history. Am J Kidney Dis 52:1042-50
Reed, Berenice Y; McFann, Kim; Bekheirnia, Mir R et al. (2008) Variation in age at ESRD in autosomal dominant polycystic kidney disease. Am J Kidney Dis 51:173-83
Tao, Yunxia; Zafar, Iram; Kim, Jun et al. (2008) Caspase-3 gene deletion prolongs survival in polycystic kidney disease. J Am Soc Nephrol 19:749-55

Showing the most recent 10 out of 79 publications