Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Ridlon, Jason M; Hylemon, Phillip B (2012) Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7?-dehydroxylating intestinal bacterium. J Lipid Res 53:66-76
Zhou, Huiping (2011) HIV protease inhibitors induce endoplasmic reticulum stress and disrupt barrier integrity in intestinal epithelial cells. Methods Enzymol 490:107-19
Zha, Weibin; Liang, Guang; Xiao, Jian et al. (2010) Berberine inhibits HIV protease inhibitor-induced inflammatory response by modulating ER stress signaling pathways in murine macrophages. PLoS One 5:e9069
Wu, Xudong; Sun, Lixin; Zha, Weibin et al. (2010) HIV protease inhibitors induce endoplasmic reticulum stress and disrupt barrier integrity in intestinal epithelial cells. Gastroenterology 138:197-209
Ridlon, Jason M; Kang, Dae-Joong; Hylemon, Phillip B (2010) Isolation and characterization of a bile acid inducible 7alpha-dehydroxylating operon in Clostridium hylemonae TN271. Anaerobe 16:137-46
Chen, Li; Jarujaron, Sirikalaya; Wu, Xudong et al. (2009) HIV protease inhibitor lopinavir-induced TNF-alpha and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages. Biochem Pharmacol 78:70-7
Rodriguez-Agudo, Daniel; Ren, Shunlin; Wong, Eric et al. (2008) Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation. J Lipid Res 49:1409-19
Wu, Xudong; Zhang, Luyong; Gurley, Emily et al. (2008) Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways. Hepatology 47:1905-15
Kang, Dae-Joong; Ridlon, Jason M; Moore 2nd, Doyle Ray et al. (2008) Clostridium scindens baiCD and baiH genes encode stereo-specific 7alpha/7beta-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductases. Biochim Biophys Acta 1781:16-25
Ren, Shunlin; Li, Xiaobo; Rodriguez-Agudo, Daniel et al. (2007) Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes. Biochem Biophys Res Commun 360:802-8

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