Abstract

Application) This is a program directed at investigating the regulation and function of genes key for glucose homeostasis. Genes expressed in the liver and/or endocrine pancreas that encode important enzymes, hormones, and transcription factors will be emphasized. All of the products of these genes are of relevance to the etiology of NIDDM: the glucokinase and hexokinase II genes, the insulin gene, and phosphoenolpyruvate carboxykinase (PEPCK) gene. Exciting new investigations are proposed for a pancreas-duodenal homeodomain gene termed PDX-l, (also known as Idx-1, STF-l and IPF-l) that holds promise for providing insights into the molecular mechanisms of pancreatic development. The projects involve a group of investigators with related interests and skills so as to stimulate frequent collaborative interactions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK042502-10
Application #
2905410
Study Section
Special Emphasis Panel (SRC (02))
Program Officer
Sato, Sheryl M
Project Start
1990-05-01
Project End
2000-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
10
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Physiology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Zhang, Juliet; Weinrich, Jarret A P; Russ, Jeffrey B et al. (2017) A Role for Dystonia-Associated Genes in Spinal GABAergic Interneuron Circuitry. Cell Rep 21:666-678
Krah, Nathan M; De La O, Jean-Paul; Swift, Galvin H et al. (2015) The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma. Elife 4:
Baeyens, Luc; Lemper, Marie; Leuckx, Gunter et al. (2014) Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat Biotechnol 32:76-83
Liu, Jing; Willet, Spencer G; Bankaitis, Eric D et al. (2013) Non-parallel recombination limits Cre-LoxP-based reporters as precise indicators of conditional genetic manipulation. Genesis 51:436-42
Kopinke, Daniel; Brailsford, Marisa; Pan, Fong Cheng et al. (2012) Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev Biol 362:57-64
Gu, Yanyun; Lindner, Jill; Kumar, Anil et al. (2011) Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Diabetes 60:827-37
Pound, Lynley D; Hang, Yan; Sarkar, Suparna A et al. (2011) The pancreatic islet ?-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer. Biochem J 433:95-105
Papizan, James B; Singer, Ruth A; Tschen, Shuen-Ing et al. (2011) Nkx2.2 repressor complex regulates islet ?-cell specification and prevents ?-to-?-cell reprogramming. Genes Dev 25:2291-305
Artner, Isabella; Hang, Yan; Mazur, Magdalena et al. (2010) MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes 59:2530-9
Masui, Toshihiko; Swift, Galvin H; Deering, Tye et al. (2010) Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells. Gastroenterology 139:270-80

Showing the most recent 10 out of 24 publications