Abstract

This Program of Excellence in Endocrinology Research aims to integrate research efforts into the study of endocrine aspects of human neoplasia. The five component projects include: 1. Endocrinology of a parathyroid-hormone-related human tumor protein; 2. Vitamin D endocrine system in human lymphoma; 3. Tumor suppressor genes in human thyroid neoplasms; 4. Mechanisms of human pituitary tumorigenesis; 5. Human ovarian cancer and p53. Three core units will provide expert multidisciplinary support to these projects. They include Administration, Laboratory, and Cytogenetics Core Laboratories. This program brings a multidisciplinary approach to study fundamental mechanisms involved in neoplastic and paraneoplastic endocrine syndromes. The synergism of these research projects will provide basic cellular and molecular insights into the pathophysiology and management of patients with tumors of endocrine organs (thyroid pituitary and ovary), and of syndromes caused by abnormal elaboration of endocrine products by non-endocrine tumors (hypercalcemia and cachexia). This will lead to further understanding of the linkage between disordered endocrine function and the neoplastic process in patients harboring both endocrine and non-endocrine tumors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
1P01DK042792-01A1
Application #
3095645
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1991-07-01
Project End
1996-06-30
Budget Start
1991-07-01
Budget End
1992-06-30
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048

  Publications

Ren, S G; Seliktar, J; Li, X et al. (1999) In vivo and in vitro regulation of thyroid leukemia inhibitory factor (LIF): marker of hypothyroidism. J Clin Endocrinol Metab 84:2883-7
Shimon, I; Hinton, D R; Weiss, M H et al. (1998) Prolactinomas express human heparin-binding secretory transforming gene (hst) protein product: marker of tumour invasiveness. Clin Endocrinol (Oxf) 48:23-9
Maeda, S; Wu, S; Green, J et al. (1998) The N-terminal portion of parathyroid hormone-related protein mediates the inhibition of apical Na+/H+ exchange in opossum kidney cells. J Am Soc Nephrol 9:175-81
Ray, D W; Ren, S G; Melmed, S (1998) Leukemia inhibitory factor regulates proopiomelanocortin transcription. Ann N Y Acad Sci 840:162-73
Ren, S G; Seliktar, J; Li, X et al. (1998) Measurement of leukemia inhibitory factor in biological fluids by radioimmunoassay. J Clin Endocrinol Metab 83:1275-83
Ren, S G; Melmed, S; Braunstein, G D (1997) Decidual leukemia inhibitory factor production and action on human chorionic gonadotropin secretion at different stages of gestation in vitro. Early Pregnancy 3:102-8
Shimon, I; Taylor, J E; Dong, J Z et al. (1997) Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation. J Clin Invest 99:789-98
Shimon, I; Melmed, S (1997) Genetic basis of endocrine disease: pituitary tumor pathogenesis. J Clin Endocrinol Metab 82:1675-81
Tasaka, T; Lee, S; Spira, S et al. (1997) Microsatellite instability during the progression of acute myelocytic leukaemia. Br J Haematol 98:219-21
Tasaka, T; Berenson, J; Vescio, R et al. (1997) Analysis of the p16INK4A, p15INK4B and p18INK4C genes in multiple myeloma. Br J Haematol 96:98-102

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