The Laboratory Core will support all six projects. The Assay Module will provide biochemical and immunochemical assays used to measure mineral regulating hormones and cytokines in Projects 1, 2, and 3. The second function of the Core Laboratory will be to operate a Cell Culture Module. This facility will be responsible for growth of cell lines (all projects), propagation of plasmids (Projects 1,3,4,5 and 6) and also provide nude mouse facilities for Projects 2,3,4,5 and 6. The third function of the Core will be to serve all projects as a Supply and Service Module. This unit will order and stock common supplies including radioisotopes, restriction enzymes, oligonucleotides, gases and buffers. Centralized cataloging and inventory control will improve cost- effectiveness and facilitate maximum usage of these expensive and perishable reagents. This core therefore provides essential expertise to facilitate performance of all the experiments proposed in this Program Project.

Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048
Ren, S G; Seliktar, J; Li, X et al. (1999) In vivo and in vitro regulation of thyroid leukemia inhibitory factor (LIF): marker of hypothyroidism. J Clin Endocrinol Metab 84:2883-7
Ray, D W; Ren, S G; Melmed, S (1998) Leukemia inhibitory factor regulates proopiomelanocortin transcription. Ann N Y Acad Sci 840:162-73
Ren, S G; Seliktar, J; Li, X et al. (1998) Measurement of leukemia inhibitory factor in biological fluids by radioimmunoassay. J Clin Endocrinol Metab 83:1275-83
Shimon, I; Hinton, D R; Weiss, M H et al. (1998) Prolactinomas express human heparin-binding secretory transforming gene (hst) protein product: marker of tumour invasiveness. Clin Endocrinol (Oxf) 48:23-9
Maeda, S; Wu, S; Green, J et al. (1998) The N-terminal portion of parathyroid hormone-related protein mediates the inhibition of apical Na+/H+ exchange in opossum kidney cells. J Am Soc Nephrol 9:175-81
Tasaka, T; Lee, S; Spira, S et al. (1997) Microsatellite instability during the progression of acute myelocytic leukaemia. Br J Haematol 98:219-21
Tasaka, T; Berenson, J; Vescio, R et al. (1997) Analysis of the p16INK4A, p15INK4B and p18INK4C genes in multiple myeloma. Br J Haematol 96:98-102
Takeuchi, S; Seriu, T; Bartram, C R et al. (1997) TEL is one of the targets for deletion on 12p in many cases of childhood B-lineage acute lymphoblastic leukemia. Leukemia 11:1220-3
Shiohara, M; Gombart, A F; Berman, J D et al. (1997) Cytostatic effect of TNFalpha on cancer cells is independent of p21WAF1. Oncogene 15:1605-9
Takeuchi, S; Koike, M; Seriu, T et al. (1997) Homozygous deletions at 9p21 in childhood acute lymphoblastic leukemia detected by microsatellite analysis. Leukemia 11:1636-40

Showing the most recent 10 out of 105 publications