Abstract

Core B will prepare, store, and distribute cells, DNA, synthetic oligonucleotides, and peptides to the program project investigators and coordinate access to the FACScan for flow cytometry. Core B will also maintain the central core data bank with clinical and laboratory data bases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK049841-05
Application #
6105712
Study Section
Project Start
1999-06-01
Project End
2000-05-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Benaroya Research Institute at Virginia Mason
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98101

  Publications

LaGasse, James M; Brantley, Michael S; Leech, Nicola J et al. (2002) Successful prospective prediction of type 1 diabetes in schoolchildren through multiple defined autoantibodies: an 8-year follow-up of the Washington State Diabetes Prediction Study. Diabetes Care 25:505-11
Nepom, G T; Lippolis, J D; White, F M et al. (2001) Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65). Proc Natl Acad Sci U S A 98:1763-8
Ettinger, R A; Liu, A W; Nepom, G T et al. (2000) Beta 57-Asp plays an essential role in the unique SDS stability of HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC allele associated with protection from insulin-dependent diabetes mellitus. J Immunol 165:3232-8
Kwok, W W; Liu, A W; Novak, E J et al. (2000) HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: direct detection of immunodominant antigen-responsive cells. J Immunol 164:4244-9
McFarland, B J; Sant, A J; Lybrand, T P et al. (1999) Ovalbumin(323-339) peptide binds to the major histocompatibility complex class II I-A(d) protein using two functionally distinct registers. Biochemistry 38:16663-70
Reichstetter, S; Kwok, W W; Nepom, G T (1999) Impaired binding of a DQ2 and DQ8-binding HSV VP16 peptide to a DQA1*0501/DQB1*0302 trans class II heterodimer. Tissue Antigens 53:101-5
Huang, S C; Glas, A M; Pinchuk, G V et al. (1999) Human B cells accumulate immunoglobulin V gene somatic mutations in a cell contact-dependent manner in cultures supported by activated T cells but not in cultures supported by CD40 ligand. Clin Exp Immunol 116:441-8
Reijonen, H; Elliott, J F; van Endert, P et al. (1999) Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB1*0401-positive individuals. J Immunol 163:1674-81
Reichstetter, S; Kwok, W W; Kochik, S et al. (1999) MHC-peptide ligand interactions establish a functional threshold for antigen-specific T cell recognition. Hum Immunol 60:608-18
Blum, J S; Ma, C; Kovats, S (1997) Antigen-presenting cells and the selection of immunodominant epitopes. Crit Rev Immunol 17:411-7

Showing the most recent 10 out of 17 publications