Abstract

This program project brings together a consortium of investigators representing biochemistry, molecular biology, cell biology, pathology, medicine, hematology, oncology, rheumatology and nephrology who, in addition to disciplinary expertise, are established researchers in the field of neutrophil biology and pathophysiology. The proposal takes the PMN membrane as its theme and presents four specific projects concerning the genomic structure of an important neutrophil adhesion protein, Phospholipid metabolism in PM membrane signal transduction, the effects of PMN membrane lipid modification on PM function, biochemistry and on inflammation in vivo, and the interface between the PMN membrane and the actin cytoskeleton. The scope of the proposed project spans the spectrum between molecular genetics, metabolism and animal pathology. Beyond the particulars of the proposal is the coming together of a critical mass of investigators and a superb advisory group dedicated to the study of nearly all aspects of the neutrophil which dictates that the whole of this project will transcend the sum of its parts.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK050305-09
Application #
2701187
Study Section
Special Emphasis Panel (SRC (30))
Program Officer
Badman, David G
Project Start
1989-09-30
Project End
2000-04-30
Budget Start
1998-05-01
Budget End
1999-04-30
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Sokol, Caroline L; Luster, Andrew D (2015) The chemokine system in innate immunity. Cold Spring Harb Perspect Biol 7:
Adair, Brian D; Xiong, Jian-Ping; Alonso, José Luis et al. (2013) EM structure of the ectodomain of integrin CD11b/CD18 and localization of its ligand-binding site relative to the plasma membrane. PLoS One 8:e57951
Gupta, Vineet; Alonso, Jose Luis; Sugimori, Takashi et al. (2008) Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function. J Immunol 180:1713-8
Gupta, Vineet; Gylling, Annette; Alonso, Jose Luis et al. (2007) The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18. Blood 109:3513-20
Sackett, Sara D; Fulmer, James T; Friedman, Joshua R et al. (2007) Foxl1-Cre BAC transgenic mice: a new tool for gene ablation in the gastrointestinal mesenchyme. Genesis 45:518-22
Colvin, Richard A; Campanella, Gabriele S V; Manice, Lindsay A et al. (2006) CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis. Mol Cell Biol 26:5838-49
Hong, Song; Tjonahen, Eric; Morgan, Elizabeth L et al. (2005) Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis. Prostaglandins Other Lipid Mediat 78:107-16
Arnaout, M A; Mahalingam, B; Xiong, J-P (2005) Integrin structure, allostery, and bidirectional signaling. Annu Rev Cell Dev Biol 21:381-410
Means, Terry K; Latz, Eicke; Hayashi, Fumitaka et al. (2005) Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest 115:407-17
Devchand, Pallavi R; Schmidt, Birgitta A; Primo, Valeria C et al. (2005) A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils. FASEB J 19:203-10

Showing the most recent 10 out of 98 publications