Abstract

The purpose of this Core is to efficiently provide purified mouse islets to investigators participating in this Program Project. Projects 2 and 2 will utilize mouse pancreatic islets in the performance of the proposed research. To provide this service, the production of mouse islets will be centralized into a single facility and available to the investigators of this program. The personal in this core will also assist in transplantation of engineered islets under the renal capsule of transplant-recipient mice. The Core will be directed by Dr. Norman Fleischer. Prioritization of its activity will be by consent of the participants of the program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK052956-05
Application #
6564321
Study Section
Project Start
2001-12-01
Project End
2003-11-30
Budget Start
Budget End
Support Year
5
Fiscal Year
2002
Total Cost
$180,000
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Type
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Lu, Zhonglei; Marcelin, Genevieve; Bauzon, Frederick et al. (2013) pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location. EMBO J 32:844-57
Kakabadze, Zurab; Gupta, Sanjeev; Brandhorst, Daniel et al. (2011) Long-term engraftment and function of transplanted pancreatic islets in vascularized segments of small intestine. Transpl Int 24:175-83
Cheng, Kang; Follenzi, Antonia; Surana, Manju et al. (2010) Switching of mesodermal and endodermal properties in hTERT-modified and expanded fetal human pancreatic progenitor cells. Stem Cell Res Ther 1:6
Brims, Daniel R; Qian, Jie; Jarchum, Irene et al. (2010) Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect. Int Immunol 22:191-203
Jarchum, Irene; DiLorenzo, Teresa P (2010) Ins2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin. J Immunol 184:658-65
Kojaoghlanian, T; Joseph, A; Follenzi, A et al. (2009) Lentivectors encoding immunosuppressive proteins genetically engineer pancreatic beta-cells to correct diabetes in allogeneic mice. Gene Ther 16:340-8
Jarchum, Irene; Takaki, Toshiyuki; DiLorenzo, Teresa P (2008) Efficient culture of CD8(+) T cells from the islets of NOD mice and their use for the study of autoreactive specificities. J Immunol Methods 339:66-73
Antal, Zoltan; Jarchum, Irene; DiLorenzo, Teresa P (2008) HLA class I supertypes in type 1 diabetic children in an urban children's hospital. Ann N Y Acad Sci 1150:86-9
Chaparro, Rodolfo Jose; Burton, Amanda R; Serreze, David V et al. (2008) Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells. J Immunol Methods 335:106-15
Inada, Mari; Follenzi, Antonia; Cheng, Kang et al. (2008) Phenotype reversion in fetal human liver epithelial cells identifies the role of an intermediate meso-endodermal stage before hepatic maturation. J Cell Sci 121:1002-13

Showing the most recent 10 out of 40 publications