Abstract

We will use genome-wide genetic mapping, large-scale DNA arrays and high-throughout DNA sequencing to identify murine candidate genes that may play a role in early hematopoiesis in determining the frequency of hematopoietic stem cells. We will also help clone and sequence Drosophila genes that may be homologues of those controlling early murine hematopoiesis. Candidate genes will be tested and biological assays developed by our collaborators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK053074-03
Application #
6201939
Study Section
Project Start
1999-09-01
Project End
2000-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Sun, Bingyun; Ma, Li; Yan, Xiaowei et al. (2013) N-glycoproteome of E14.Tg2a mouse embryonic stem cells. PLoS One 8:e55722
Bockhorn, Jessica; Yee, Kathy; Chang, Ya-Fang et al. (2013) MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. Breast Cancer Res Treat 137:373-82
Heffner, Garrett C; Clutter, Matthew R; Nolan, Garry P et al. (2011) Novel hematopoietic progenitor populations revealed by direct assessment of GATA1 protein expression and cMPL signaling events. Stem Cells 29:1774-82
Yan, Xiaowei; Ma, Li; Yi, Danielle et al. (2011) A CD133-related gene expression signature identifies an aggressive glioblastoma subtype with excessive mutations. Proc Natl Acad Sci U S A 108:1591-6
Forsberg, E Camilla; Passegué, Emmanuelle; Prohaska, Susan S et al. (2010) Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells. PLoS One 5:e8785
Jaiswal, Siddhartha; Chao, Mark P; Majeti, Ravindra et al. (2010) Macrophages as mediators of tumor immunosurveillance. Trends Immunol 31:212-9
Inaba, Mayu; Yuan, Hebao; Salzmann, Viktoria et al. (2010) E-cadherin is required for centrosome and spindle orientation in Drosophila male germline stem cells. PLoS One 5:e12473
Ooi, A G Lisa; Karsunky, Holger; Majeti, Ravindra et al. (2009) The adhesion molecule esam1 is a novel hematopoietic stem cell marker. Stem Cells 27:653-61
Papathanasiou, Peter; Attema, Joanne L; Karsunky, Holger et al. (2009) Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150. Stem Cells 27:2498-508
Majeti, Ravindra; Becker, Michael W; Tian, Qiang et al. (2009) Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc Natl Acad Sci U S A 106:3396-401

Showing the most recent 10 out of 38 publications