The sequence of events culminating in a renal calculus of clinically significant size remains to be established. Our work with thorough clinical, endoscopic, metabolic, and histologic examination of stone formers (SF) suggests that specific physiologic events in the kidney result in characteristic patterns of crystal deposition and eventual stones.
Aim 1 will extend our work, which began with the confirmation and elaboration of the work of Randall in common calcium oxalate SF and is extending to include other crystal deposits and stone phenotypes.
In Aim 2 we hypothesize that rigorous examination of common calcium oxalate SF undergoing endoscopic stone removal will demonstrate either stone attached to plaque or evidence of plaque in any non-attached stones. As with Aim 1, the protocol of Aim 2 will be extended to other stone phenotypes. With the development of multi-detector CT technology, non-invasive visualization of Randall's plaque (RP) is now possible. Using our now well established endoscopic mapping techniques as a standard, Aim 3 will attempt to define and quantitate CT plaque characteristics and will investigate radiographic criteria for distinguishing RP from stone. Finally, Aim 4 will explore the relationship of urinary stasis to stone formation, a topic that heretofore has not been subjected to rigorous science. Two models (calyceal diverticula, ureteropelvic junction obstruction) will be utilized in this Aim.
| Williams Jr, James C; Borofsky, Michael S; Bledsoe, Sharon B et al. (2018) Papillary Ductal Plugging is a Mechanism for Early Stone Retention in Brushite Stone Disease. J Urol 199:186-192 |
| Worcester, Elaine M; Bergsland, Kristin J; Gillen, Daniel L et al. (2018) Mechanism for higher urine pH in normal women compared with men. Am J Physiol Renal Physiol 314:F623-F629 |
| Bergsland, Kristin J; Coe, Fredric L; Parks, Joan H et al. (2018) Evidence for a role of PDZ domain-containing proteins to mediate hypophosphatemia in calcium stone formers. Nephrol Dial Transplant 33:759-770 |
| Kleinguetl, Colin; Williams Jr, James C; Ibrahim, Samar A et al. (2017) Calcium Tartrate Tetrahydrate, Case Report of a Novel Human Kidney Stone. J Endourol Case Rep 3:192-195 |
| Mulay, Shrikant R; Eberhard, Jonathan N; Desai, Jyaysi et al. (2017) Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease. J Am Soc Nephrol 28:761-768 |
| Winfree, Seth; Khan, Shehnaz; Micanovic, Radmila et al. (2017) Quantitative Three-Dimensional Tissue Cytometry to Study Kidney Tissue and Resident Immune Cells. J Am Soc Nephrol 28:2108-2118 |
| Borofsky, Michael S; Dauw, Casey A; York, Nadya et al. (2017) Accuracy of daily fluid intake measurements using a ""smart"" water bottle. Urolithiasis : |
| Winfree, Seth; Ferkowicz, Michael J; Dagher, Pierre C et al. (2017) Large-scale 3-dimensional quantitative imaging of tissues: state-of-the-art and translational implications. Transl Res 189:1-12 |
| Cohen, Andrew J; Borofsky, Michael S; Anderson, Blake B et al. (2017) Endoscopic Evidence That Randall's Plaque is Associated with Surface Erosion of the Renal Papilla. J Endourol 31:85-90 |
| Gilad, Ron; Williams Jr, James C; Usman, Kalba D et al. (2017) Interpreting the results of chemical stone analysis in the era of modern stone analysis techniques. J Nephrol 30:135-140 |
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