Transgenic Mouse Core The mouse core is devoted to breeding of all non-commercially available murine lines, and the maintenance and distribution of these mice for use in experiments required to achieve the aims of this Program. In addition, the core will absorb all animal care costs generated by these projects. The existence of such a core is justified by the significant overlap among investigators of transgenic lines used in the various projects, and the fact that many experiments will be performed as collaborative efforts. It is anticipated that there will be qual use of the animal core by all investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK057644-02
Application #
6468437
Study Section
Special Emphasis Panel (ZDK1)
Project Start
2001-06-01
Project End
2002-05-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2001
Total Cost
$221,356
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Martinez, Xavier; Kreuwel, Huub T C; Redmond, William L et al. (2005) CD8+ T cell tolerance in nonobese diabetic mice is restored by insulin-dependent diabetes resistance alleles. J Immunol 175:1677-85
Yadav, Deepak; Judkowski, Valeria; Flodstrom-Tullberg, Malin et al. (2004) B7-2 (CD86) controls the priming of autoreactive CD4 T cell response against pancreatic islets. J Immunol 173:3631-9
Redmond, William L; Hernandez, Javier; Sherman, Linda A (2003) Deletion of naive CD8 T cells requires persistent antigen and is not programmed by an initial signal from the tolerogenic APC. J Immunol 171:6349-54
Kreuwel, H T; Biggs, J A; Pilip, I M et al. (2001) Defective CD8+ T cell peripheral tolerance in nonobese diabetic mice. J Immunol 167:1112-7
Pakala, S V; Ilic, A; Chen, L et al. (2001) TNF-alpha receptor 1 (p55) on islets is necessary for the expression of LIGHT on diabetogenic T cells. Clin Immunol 100:198-207
Kreuwel, H T; Sherman, L A (2001) Defects in deletional tolerance of CD8+ T cells in autoimmune diabetes. Curr Dir Autoimmun 4:123-43
Kreuwel, H T; Sherman, L A (2001) The role of Fas-FasL in CD8+ T-cell-mediated insulin-dependent diabetes mellitus (IDDM). J Clin Immunol 21:15-8
Kreuwel, H T; Sherman, L A (2001) The T-cell repertoire available for recognition of self-antigens. Curr Opin Immunol 13:639-43
Murtaza, A; Nugent, C T; Tailor, P et al. (2001) Altered functional and biochemical response by CD8+ T cells that remain after tolerance. Int Immunol 13:1085-93