The purpose of the Translational Core (Core D) is to provide access to human tissue, genetic material, clinical data, and statistical support to determine the clinical relevance of the biological questions being investigated in the projects of this Program Project Grant. Archived liver biopsies stored by the Department of Pathology plus the Yale Liver Center's patient registry and serum, DNA and tissue specimens will be available, which in total represents specimens and/or patient data from nearly 20,000 unique patients. The Core's Liver Pathologist and Research Coordinator will work with the Project Leaders to identify, retrieve and interpret relevant bio- specimens and handle necessary IRB protocols. The Core's statistician will work with the Project Leaders and Translational Core staff to address power analyses, sample sizes, and other relevant statistical considerations. This core will enable each Project Leader to relate their basic observations in cells and animal models to changes in expression and tissue localization of the corresponding genes and proteins of interest in patients under normal conditions and in specific liver disease states.
The purpose of this core is to provide access to human tissue, genetic material, clinical data, and statistical support to determine the clinical relevance of the biological questions being investigated in this Program Project Grant. This will enable basic observations in cells and animal models to be related to changes in expression and tissue localization of the corresponding genes and proteins of interest in patients under normal conditions and in specific liver disease states.
| Qian, Kevin; Wang, Simeng; Fu, Minnie et al. (2018) Transcriptional regulation of O-GlcNAc homeostasis is disrupted in pancreatic cancer. J Biol Chem 293:13989-14000 |
| Boeckel, Göran R; Ehrlich, Barbara E (2018) NCS-1 is a regulator of calcium signaling in health and disease. Biochim Biophys Acta Mol Cell Res : |
| Lawan, Ahmed; Min, Kisuk; Zhang, Lei et al. (2018) Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance. Diabetes 67:624-635 |
| Franca, Andressa; Filho, Antonio Carlos Melo Lima; Guerra, Mateus T et al. (2018) Effects of endotoxin on type 3 inositol 1,4,5-trisphosphate receptor in human cholangiocytes. Hepatology : |
| Lemos, Fernanda O; Ehrlich, Barbara E (2018) Polycystin and calcium signaling in cell death and survival. Cell Calcium 69:37-45 |
| Giehl, Esther; Lemos, Fernanda O; Huang, Yan et al. (2017) Polycystin 2-dependent cardio-protective mechanisms revealed by cardiac stress. Pflugers Arch 469:1507-1517 |
| Feriod, Colleen N; Oliveira, Andre Gustavo; Guerra, Mateus T et al. (2017) Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver. Hepatol Commun 1:23-35 |
| Kruglov, Emma; Ananthanarayanan, Meenakshisundaram; Sousa, Pedro et al. (2017) Type 2 inositol trisphosphate receptor gene expression in hepatocytes is regulated by cyclic AMP. Biochem Biophys Res Commun 486:659-664 |
| Lawan, Ahmed; Bennett, Anton M (2017) Mitogen-Activated Protein Kinase Regulation in Hepatic Metabolism. Trends Endocrinol Metab 28:868-878 |
| Ruan, Hai-Bin; Ma, Yina; Torres, Sara et al. (2017) Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation. Genes Dev 31:1655-1665 |
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