Abstract

application) The main goal of this core is to support and optimize the activities of the program investigators performing studies with pediatric samples. The core services will include a. identify, classify, register and follow up pediatric IBD and control patients, b. record and provide all relevant clinical information, and c. procure, store and transport mucosal biopsy samples, surgical specimens and blood samples. The clinical resources for this core include the children senn at the Division of Pediatric Gastroenterology and Nutrition at Rainbow Babies and Children?s Hospital. Projects 1 and 4 will utilize the samples provided by this core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK057756-03
Application #
6652809
Study Section
Special Emphasis Panel (ZDK1)
Project Start
2002-09-15
Project End
2003-09-14
Budget Start
Budget End
Support Year
3
Fiscal Year
2002
Total Cost
$147,138
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Danese, Silvio; Sans, Miquel; Spencer, David M et al. (2007) Angiogenesis blockade as a new therapeutic approach to experimental colitis. Gut 56:855-62
Kugathasan, S; Saubermann, L J; Smith, L et al. (2007) Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease. Gut 56:1696-705
Etling, Michele R; Davies, Sarah; Campbell, Melanie et al. (2007) Maturation of the mucosal immune system underlies colitis susceptibility in interleukin-10-deficient (IL-10-/-) mice. J Leukoc Biol 82:311-9
Day, Anthony J; de la Motte, Carol A (2005) Hyaluronan cross-linking: a protective mechanism in inflammation? Trends Immunol 26:637-43
Drakes, Maureen L; Blanchard, Thomas G; Czinn, Steven J (2005) Colon lamina propria dendritic cells induce a proinflammatory cytokine response in lamina propria T cells in the SCID mouse model of colitis. J Leukoc Biol 78:1291-300
Stallion, Anthony; Kou, Tzuyung D; Latifi, Samir Q et al. (2005) Ischemia/reperfusion: a clinically relevant model of intestinal injury yielding systemic inflammation. J Pediatr Surg 40:470-7
Manley, Mollie O; O'Riordan, Mary Ann; Levine, Alan D et al. (2005) Interleukin 10 extends the effectiveness of standard therapy during late sepsis with serum interleukin 6 levels predicting outcome. Shock 23:521-6
Matsumoto, Yuko; Blanchard, Thomas G; Drakes, Maureen L et al. (2005) Eradication of Helicobacter pylori and resolution of gastritis in the gastric mucosa of IL-10-deficient mice. Helicobacter 10:407-15
Basu, Malini; Czinn, Steven J; Blanchard, Thomas G (2004) Absence of catalase reduces long-term survival of Helicobacter pylori in macrophage phagosomes. Helicobacter 9:211-6
Jump, Robin L; Levine, Alan D (2004) Mechanisms of natural tolerance in the intestine: implications for inflammatory bowel disease. Inflamm Bowel Dis 10:462-78

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