Abstract

The Administrative Core consists of the overall Project Director/Principal Investigator (Dr. Schwartz), a50%-time Program Coordinator and a 30%-time secretary. Dr. Schwartz is responsible for all aspects of theprogram Project. With the assistance of the other personnel, Dr. Schwartz will handle the day-to-dayadministrative duties and oversee all activities of all projects and cores at all times. Dr. Schwartz will alsocall regular meetings of the Executive Committee and External Advisory Committee, and he is responsiblefor all progress reports and annual submission of non-competing renewals and requests for supplementalfunding.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK068384-05
Application #
7663939
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
5
Fiscal Year
2008
Total Cost
$98,917
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

O-Sullivan, InSug; Zhang, Wenwei; Wasserman, David H et al. (2015) FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization. Nat Commun 6:7079
Lee, Woo Je; Tateya, Sanshiro; Cheng, Andrew M et al. (2015) M2 Macrophage Polarization Mediates Anti-inflammatory Effects of Endothelial Nitric Oxide Signaling. Diabetes 64:2836-46
Morton, Gregory J; Kaiyala, Karl J; Foster-Schubert, Karen E et al. (2014) Carbohydrate feeding dissociates the postprandial FGF19 response from circulating bile acid levels in humans. J Clin Endocrinol Metab 99:E241-5
Lu, Min; Sarruf, David A; Li, Pingping et al. (2013) Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. J Biol Chem 288:10722-35
Schwartz, Michael W; Baskin, Denis G (2013) Leptin and the brain: then and now. J Clin Invest 123:2344-5
Guyenet, Stephan J; Nguyen, Hong T; Hwang, Bang H et al. (2013) High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes. Brain Res 1512:97-105
Thaler, Joshua P; Yi, Chun-Xia; Schur, Ellen A et al. (2012) Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest 122:153-62
Schwartz, Michael W (2012) An inconvenient truth about obesity. Mol Metab 1:2-4
Guyenet, Stephan J; Schwartz, Michael W (2012) Clinical review: Regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity. J Clin Endocrinol Metab 97:745-55
Lu, Min; Sarruf, David A; Talukdar, Saswata et al. (2011) Brain PPAR-? promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nat Med 17:618-22

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