Abstract

The purpose of this core is to provide the leadership and administrative support for the overall Program Project. Even though all of the Project and Core Leaders are members of the Brigham and Women's Hospital Renal Division, substantial effort will be needed to direct this Program Project and this will be provided by Dr. Curhan (also the overall PI for the Program Project). The administrative support will ensure maximal productivity during the funding period and will also guarantee close coordination and communication among the investigators and with the Advisory Committee. The Project Leaders will meet formally at least monthly to discuss scientific and administrative issues related to the Program Project. We will also meet formally with our Advisory Committee on an annual basis and with individual members of the Advisory Committee as needed during the year. Because of the substantial leadership and administrative experience of the Core Leader, the intimate involvement with the ongoing Nurses'Health Study I, Nurses' Health Study II and Health Professionals Follow-up Study, and the already existing close interactions among all the Project Leaders, this Program Project can be implemented efficiently, smoothly and successfully with the resources requested in the Administrative Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK070756-04
Application #
8137958
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
4
Fiscal Year
2010
Total Cost
$107,972
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Mandal, Asim K; Mercado, Adriana; Foster, Andria et al. (2017) Uricosuric targets of tranilast. Pharmacol Res Perspect 5:e00291
Pirastu, Nicola; Joshi, Peter K; de Vries, Paul S et al. (2017) GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. Nat Commun 8:1584
Canales, Benjamin K; Smith, Jennifer A; Weiner, I David et al. (2017) Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH. Kidney Int Rep 2:1111-1121
Ibrahim-Verbaas, C A; Bressler, J; Debette, S et al. (2016) GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Mol Psychiatry 21:189-197
Cornelis, Marilyn C; Flint, Alan; Field, Alison E et al. (2016) A genome-wide investigation of food addiction. Obesity (Silver Spring) 24:1336-41
Huang, Tao; Zheng, Yan; Qi, Qibin et al. (2015) DNA Methylation Variants at HIF3A Locus, B-Vitamin Intake, and Long-term Weight Change: Gene-Diet Interactions in Two U.S. Cohorts. Diabetes 64:3146-54
Debette, Stéphanie; Ibrahim Verbaas, Carla A; Bressler, Jan et al. (2015) Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Biol Psychiatry 77:749-63
Huang, Tao; Qi, Qibin; Zheng, Yan et al. (2015) Genetic Predisposition to Central Obesity and Risk of Type 2 Diabetes: Two Independent Cohort Studies. Diabetes Care 38:1306-11
Zimmermann, E; Ängquist, L H; Mirza, S S et al. (2015) Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults. Obes Rev 16:327-340
Gottlieb, D J; Hek, K; Chen, T-H et al. (2015) Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. Mol Psychiatry 20:1232-9

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