Abstract

The Allergy/Immunology unit of the Core will be responsible for all aspects of the exposure of animals to allergen and establishment of validation of an immunological response. These include skin testing of all animals for allergens prior to the beginning of allergen exposure and periodically during the exposure period. They will purify all allergens prior to exposure and analyze blood components for immunoglobulins, histamine, and expression of other mediators characteristic of the development of asthma during the allergen exposure. The unit is divided into four phases: 1) Initial Screening of Monkeys, 2) Allergen Sensitization Protocol, 3) Skin Testing Protocol, and 4) Immunological Evaluation. They now present preliminary data that confirms their ability to both sensitize adult and neonate rhesus to HDMA, with an increase of HDM specific serum IgE in the Ozone and allergen group.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES000628-29
Application #
6656491
Study Section
Special Emphasis Panel (ZES1)
Project Start
2002-09-04
Project End
2003-06-30
Budget Start
Budget End
Support Year
29
Fiscal Year
2002
Total Cost
$157,209
Indirect Cost

  Institution

Name
University of California Davis
Department
Type
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Crowley, Candace M; Fontaine, Justin H; Gerriets, Joan E et al. (2017) Early life allergen and air pollutant exposures alter longitudinal blood immune profiles in infant rhesus monkeys. Toxicol Appl Pharmacol 328:60-69
Lynn, Therese M; Molloy, Emer L; Masterson, Joanne C et al. (2016) SMAD Signaling in the Airways of Healthy Rhesus Macaques versus Rhesus Macaques with Asthma Highlights a Relationship Between Inflammation and Bone Morphogenetic Proteins. Am J Respir Cell Mol Biol 54:562-73
Hsia, Connie C W; Hyde, Dallas M; Weibel, Ewald R (2016) Lung Structure and the Intrinsic Challenges of Gas Exchange. Compr Physiol 6:827-95
Herring, Matt J; Avdalovic, Mark V; Lasley, Bill et al. (2016) Elderly Female Rhesus Macaques Preserve Lung Alveoli With Estrogen/Progesterone Therapy. Anat Rec (Hoboken) 299:973-8
Herring, M J; Putney, L F; St George, J A et al. (2015) Early life exposure to allergen and ozone results in altered development in adolescent rhesus macaque lungs. Toxicol Appl Pharmacol 283:35-41
Van Winkle, Laura S; Bein, Keith; Anderson, Donald et al. (2015) Biological dose response to PM2.5: effect of particle extraction method on platelet and lung responses. Toxicol Sci 143:349-59
Madl, Amy K; Plummer, Laurel E; Carosino, Christopher et al. (2014) Nanoparticles, lung injury, and the role of oxidant stress. Annu Rev Physiol 76:447-65
Herring, Matt J; Putney, Lei F; Wyatt, Gregory et al. (2014) Growth of alveoli during postnatal development in humans based on stereological estimation. Am J Physiol Lung Cell Mol Physiol 307:L338-44
Moore, Brian D; Hyde, Dallas M; Miller, Lisa A et al. (2014) Persistence of serotonergic enhancement of airway response in a model of childhood asthma. Am J Respir Cell Mol Biol 51:77-85
Murphy, Shannon R; Oslund, Karen L; Hyde, Dallas M et al. (2014) Ozone-induced airway epithelial cell death, the neurokinin-1 receptor pathway, and the postnatal developing lung. Am J Physiol Lung Cell Mol Physiol 307:L471-81

Showing the most recent 10 out of 62 publications