Biomarkers for Human Reproductive Epidemiology

Lasley, Bill

Abstract

In this project, we will identify new urinary biomarkers for use in epidemiological studies of women's reproductive health. More sensitive laboratory assays will be developed for biomarkers of ovarian function and early fetal loss (EFL). Immunoassays for urinary human chorionic gonadotropin (hCG), follicle stimulating hormone (FSH), and subunits, as well as assays for luteinizing hormone (LH) and FSH bioactivity in urine will be developed. Prediction rules based on multiple biomarkers of trophoblastic and ovarian function will be used to identify previously unrecognized EFL in population-based studies. A similar approach will be used to identify anovulatory cycles in studies of menstrual function and infertility. Clinical research studies will provide basic information to be used in developing methodology for identifying the target organ of toxicity in cases of ovulation failure and EFL. The environmental and lifestyle variables which may affect these outcomes will be studied in a population of free-living women. The goal of this project is to enable epidemiologists to extend their observations beyond the identification of adverse effects and allow them to focus on the target of reproductive toxicity at the organ system level.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Research Program Projects (P01)
• Project #: 1P01ES006198-01A1
• Application #: 3777430
• Support Year: 1
• Fiscal Year: 1993

Institution

• Name: University of California Davis
• DUNS #: 094878337
• City: Davis
• State: CA
• Country: United States
• Zip Code: 95618

Publications

Lasley, B L; Crawford, S L; McConnell, D S (2013) Ovarian adrenal interactions during the menopausal transition. Minerva Ginecol 65:641-51

Moran, Francisco M; Chen, Jiangang; Gee, Nancy A et al. (2013) Dehydroepiandrosterone sulfate levels reflect endogenous luteinizing hormone production and response to human chorionic gonadotropin challenge in older female macaque (Macaca fascicularis). Menopause 20:329-35

Conley, Alan J; Stanczyk, Frank Z; Morrison, John H et al. (2013) Modulation of higher-primate adrenal androgen secretion with estrogen-alone or estrogen-plus-progesterone intervention. Menopause 20:322-8

Lasley, Bill L; Crawford, Sybil L; Laughlin, Gail A et al. (2011) Circulating dehydroepiandrosterone sulfate levels in women who underwent bilateral salpingo-oophorectomy during the menopausal transition. Menopause 18:494-8

Lei, Lou; Ye, Linan; Liu, Hong et al. (2008) Passive smoking, cytochrome P450 gene polymorphisms and dysmenorrhea. Eur J Epidemiol 23:475-81

Chen, Jiangang; Ahn, Ki Chang; Gee, Nancy A et al. (2008) Triclocarban enhances testosterone action: a new type of endocrine disruptor? Endocrinology 149:1173-9

Li, Na; Liu, Hong; Chen, Changzhong et al. (2007) CYP1A1 gene polymorphisms in modifying the association between passive smoking and primary dysmenorrhea. Ann Epidemiol 17:882-8

Wu, Ting; Hu, Yonghua; Chen, Changzhong et al. (2007) Passive smoking, metabolic gene polymorphisms, and infant birth weight in a prospective cohort study of Chinese women. Am J Epidemiol 166:313-22

Chen, Jiangang; Ahn, Ki Chang; Gee, Nancy A et al. (2007) Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol Appl Pharmacol 221:278-84

Liu, Hong; Yang, Fan; Li, Zhiping et al. (2007) Passive smoking, Cyp1A1 gene polymorphism and dysmenorrhea. Reprod Toxicol 24:114-9