Abstract

The animal and nutrition core will provide the investigators animals for the animal studies proposed by the PI's. The animals that will provided are rats, gerbils and mice. In addition, the core will provide nine different transgenic mice, including hormone receptor knock out mice. The direction of the animal core facility will be the overall PI of the Center grant, Dr. Lubahn. Dr. Lubahn has generated during the last 10 years a number of K0 mice and has been actively involved in hormone receptor studies with regards to the effect of phytoestrogens on breast and prostate carcinoma. The direction of the Nutrition Core facility will be Dr. Ruth MacDonald. Dr. MacDonald will be in charge of the production and the supply of the various diets. Her studies are focusing on understanding of the relationship between zinc diets. Her studies are focusing on understanding the relationship between zinc diets. her studies are focusing on understanding the relationship between zinc and growth factors on the regulation of cell division. Her current projects include the effects of phytoestrogens on Colon cancer as well as fatty acid and the effect of fatty acids on prostate cancer. The other members involved in the animal core appear well qualified and capable of maintaining their core facility.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
1P01ES010535-01
Application #
6359992
Study Section
Special Emphasis Panel (ZRG1-BNP (02))
Project Start
2000-03-01
Project End
2005-02-28
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
$65,390
Indirect Cost

  Institution

Name
University of Missouri-Columbia
Department
Type
DUNS #
112205955
City
Columbia
State
MO
Country
United States
Zip Code
65211

  Publications

Lei, Wei; Browning Jr, Jimmy D; Eichen, Peggy A et al. (2015) Immuno-stimulatory activity of a polysaccharide-enriched fraction of Sutherlandia frutescens occurs by the toll-like receptor-4 signaling pathway. J Ethnopharmacol 172:247-53
Slusarz, Anna; Jackson, Glenn A; Day, J Kevin et al. (2012) Aggressive prostate cancer is prevented in ER?KO mice and stimulated in ER?KO TRAMP mice. Endocrinology 153:4160-70
Brown, Marybeth; Ning, Jie; Ferreira, J Andries et al. (2009) Estrogen receptor-alpha and -beta and aromatase knockout effects on lower limb muscle mass and contractile function in female mice. Am J Physiol Endocrinol Metab 296:E854-61
Richter, Catherine A; Taylor, Julia A; Ruhlen, Rachel L et al. (2007) Estradiol and Bisphenol A stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells. Environ Health Perspect 115:902-8
Zhou, Wei; Lo, Shih-Ching; Liu, Jing-Hua et al. (2007) ERRbeta: a potent inhibitor of Nrf2 transcriptional activity. Mol Cell Endocrinol 278:52-62
Curran, Edward M; Tassell, Audrey Hart-Van; Judy, Barbara M et al. (2007) Estrogen increases menopausal host susceptibility to experimental ascending urinary-tract infection. J Infect Dis 195:680-3
Wang, Qun; Tompkins, Kenneth D; Simonyi, Agnes et al. (2006) Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. Brain Res 1090:182-9
Zhou, Wei; Liu, Zhilin; Wu, Jianbo et al. (2006) Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta. J Clin Endocrinol Metab 91:569-79
Wang, Qun; Yu, Sue; Simonyi, Agnes et al. (2005) Kainic acid-mediated excitotoxicity as a model for neurodegeneration. Mol Neurobiol 31:3-16
Lambert, K Chad; Curran, Edward M; Judy, Barbara M et al. (2005) Estrogen receptor alpha (ERalpha) deficiency in macrophages results in increased stimulation of CD4+ T cells while 17beta-estradiol acts through ERalpha to increase IL-4 and GATA-3 expression in CD4+ T cells independent of antigen presentation. J Immunol 175:5716-23

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