Public Health Relevance

The proposed analysis will pool data from 14 studies across 10 countries to form the largest study of childhood leukemia to investigate the possible link between childhood leukemia and parental tobacco smoking or home pesticide exposures. The results of this study may provide scientific knowledge and inform policy making to effectively prevent and reduce the occurrence of childhood leukemia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
1P01ES018172-01
Application #
7852178
Study Section
Special Emphasis Panel (ZES1-LKB-G (P1))
Project Start
Project End
Budget Start
2009-09-25
Budget End
2010-07-31
Support Year
1
Fiscal Year
2009
Total Cost
$81,756
Indirect Cost
Name
University of California Berkeley
Department
Type
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Wallace, Amelia D; Francis, Stephen S; Shao, Xiaorong et al. (2018) A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology. Haematologica 103:e29-e31
Wiemels, Joseph L; Walsh, Kyle M; de Smith, Adam J et al. (2018) GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nat Commun 9:286
Petridou, Eleni Th; Georgakis, Marios K; Erdmann, Friederike et al. (2018) Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium. Eur J Epidemiol :
Rappaport, Stephen M (2018) Redefining environmental exposure for disease etiology. NPJ Syst Biol Appl 4:30
de Smith, Adam J; Walsh, Kyle M; Francis, Stephen S et al. (2018) BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia. Int J Cancer 143:2647-2658
Edmands, William M B; Hayes, Josie; Rappaport, Stephen M (2018) SimExTargId: a comprehensive package for real-time LC-MS data acquisition and analysis. Bioinformatics 34:3589-3590
Felix, Janine F; Joubert, Bonnie R; Baccarelli, Andrea A et al. (2018) Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. Int J Epidemiol 47:22-23u
Wang, Rong; Metayer, Catherine; Morimoto, Libby et al. (2017) Parental Age and Risk of Pediatric Cancer in the Offspring: A Population-Based Record-Linkage Study in California. Am J Epidemiol 186:843-856
de Smith, Adam J; Kaur, Maneet; Gonseth, Semira et al. (2017) Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia. Cancer Res 77:1674-1683
Petrick, Lauren; Edmands, William; Schiffman, Courtney et al. (2017) An untargeted metabolomics method for archived newborn dried blood spots in epidemiologic studies. Metabolomics 13:

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