The proposed new Children's Environmental Health Center based at the University of California, Berkeley is designed to examine the effects of in utero and early life exposure to potentially carcinogenic chemicals present in homes (i.e., pesticides, tobacco-related and epigenetic factors and their interplay in the development of childhood leukemia. The proposed Center, referred to as Center for Interdisciplinary Research on Childhood Leukemia and the Environment (CIRCLE) includes three Research Projects and two Cores as follows: Project 1 (Childhood Leukemia International Consortium Studies) will identify the exposures to the most relevant time periods and childhood leukemia subtypes and identify important genetic polymorphisms that can modify the association between childhood leukemia and parental tobacco smoking or home pesticide exposure by pooling data from 19 studies worldwide;Project 2 (Exposure Assessment for Childhood Leukemia) y /ill assess carcinogen exposures, based upon analysis of house dust and blood specimens, with special interest in tobacco-related contaminants, PCBs, and PBDEs;Project 3 (Prenatal exposures, DNA Methylation, &Childhood Leukemia) will provide a clearer understanding of the association between parental smoking, pesticides, PCBs, PBDEs exposures and DNA methylation patterns in childhood leukemia, using neonatal bloods. The Research Translation and Community Outreach Core (RTCO Core) will disseminate findings from each Project to various audiences with common interest in the etiology of childhood leukemia. The main objectives of Core A are to provide 1) oversight, coordination, and integration of Center activities;2) scientific leadership;and 3) centralized data management support. Core A will establish and manage Internal and External Advisory Committees;appoint and collaborate with two Pediatric Health Specialists, and support the research career development of new, junior faculty-level investigators within the structure of the Center. Core A will coordinate Community Engagement through the RTCO Core, assisted by the pediatric Health Specialists.

Public Health Relevance

The purpose of this Program is to assess the role played by potentially cancer-causing chemicals in the risk of childhood leukemia. We will work with an international consortium of epidemiologic studies, and use stateof- the-art methods to both measure these chemicals and establish epigenetic mechanisms by which they influence risk. Outreach efforts will disseminate results to the community and policymakers.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES018172-02
Application #
7939617
Study Section
Special Emphasis Panel (ZES1-LKB-G (P1))
Program Officer
Gray, Kimberly A
Project Start
2009-09-25
Project End
2014-07-31
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
2
Fiscal Year
2010
Total Cost
$735,324
Indirect Cost
Name
University of California Berkeley
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
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Wallace, Amelia D; Francis, Stephen S; Shao, Xiaorong et al. (2018) A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology. Haematologica 103:e29-e31
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de Smith, Adam J; Kaur, Maneet; Gonseth, Semira et al. (2017) Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia. Cancer Res 77:1674-1683
Petrick, Lauren; Edmands, William; Schiffman, Courtney et al. (2017) An untargeted metabolomics method for archived newborn dried blood spots in epidemiologic studies. Metabolomics 13:

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