The developmental origins hypothesis relates early exposures to endocrine disrupting chemicals (EDCs) to the development of chronic diseases, including metabolic syndrome, a condition affecting up to 25% of US adults and 30% of obese adolescents. Limited research in humans has considered the mechanisms by which exposures to EDCs mixtures interact with diet to alter maternal and child metabolic homeostasis, nor considered whether subsequent exposures during adolescence exacerbate risk of metabolic syndrome. Pilot human and animal data from our Formative CEHC: 'Perinatal exposures, epigenetics, child obesity and sexual maturation"""""""" (P20 ESDI 8171/ RD834800, Pl: Peterson) suggest that the disruptive effects of representative maternal EDCs on metabolic and epigenetic markers may differ across sensitive periods of child development. Drawing on unparalleled institutional resources including the UM NIEHS Center of Excellence Epigenetics Laboratory (P30 ES017885) and the Michigan Nutrition and Obesity Research Center (MNORC, P30 DK089503), this project will test the hypothesis that EDC mixtures (BPA, phthalates, lead, cadmium) via epigenetic mechanisms induce oxidative stress (tyrosine oxidation products), disrupt metabolic homeostasis (free fatty acids, amino acids, Acyl-carnitine) and lead to changes in gene transcription and metabolic function. We further hypothesize that dietary macro- and micronutrient intake and dietary patterns during pregnancy and adolescence will modify the impact of EDC mixtures on these outcomes. Study participants include the Michigan Mother-Infant Pairs (MMIP) cohort (n=80) (extension of R01 ES017005, PI: Padmanabhan) and 400 children followed from pregnancy to 8-15 years of age through our 18-yr Early Life Exposures in Mexico to ENvironmental Toxicants (ELEMENT) collaboration with Mexico's Instituto Nacional de Salud Publica (INSP). Findings will: 1) provide proof of concept that EDC mixtures perturb metabolic homeostasis, 2) clarify the role of diet in amplifying or negating such effects, 3) illustrate the epigenetic and transcriptional changes involved and 4) inform the design of future interventions to modify metabolic consequences of EDC exposures both in utero and during the pubertal transition.

Public Health Relevance

Metabolic syndrome affects ~25% of U.S. adults and up to 30% of obese adolescents. Understanding how exposures to EDCs during pregnancy and adolescence may interact with diet to lead to metabolic dysregulation is .highly relevant to clinical and public health practice. Results of this study will inform design of interventions to reduce health effects of toxicant mixtures in children during key developmental periods.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
1P01ES022844-01
Application #
8533647
Study Section
Special Emphasis Panel (ZES1-LKB-K (P0))
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-05-31
Support Year
1
Fiscal Year
2013
Total Cost
$236,890
Indirect Cost
$60,040
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Perng, Wei; Tang, Lu; Song, Peter X K et al. (2018) Metabolomic profiles and development of metabolic risk during the pubertal transition: a prospective study in the ELEMENT Project. Pediatr Res :
Ferguson, Kelly K; Meeker, John D; Cantonwine, David E et al. (2018) Environmental phenol associations with ultrasound and delivery measures of fetal growth. Environ Int 112:243-250
Jansen, Erica C; Dunietz, Galit Levi; Chervin, Ronald D et al. (2018) Adiposity in Adolescents: The Interplay of Sleep Duration and Sleep Variability. J Pediatr 203:309-316
Kochmanski, Joseph J; Marchlewicz, Elizabeth H; Cavalcante, Raymond G et al. (2018) Longitudinal Effects of Developmental Bisphenol A Exposure on Epigenome-Wide DNA Hydroxymethylation at Imprinted Loci in Mouse Blood. Environ Health Perspect 126:077006
Rodríguez-Carmona, Yanelli; Cantoral, Alejandra; Trejo-Valdivia, Belem et al. (2018) Phthalate exposure during pregnancy and long-term weight gain in women. Environ Res 169:26-32
Banu, Sakhila K; Stanley, Jone A; Taylor, Robert J et al. (2018) Sexually Dimorphic Impact of Chromium Accumulation on Human Placental Oxidative Stress and Apoptosis. Toxicol Sci 161:375-387
Lewis, Ryan C; Meeker, John D; Basu, Niladri et al. (2018) Urinary metal concentrations among mothers and children in a Mexico City birth cohort study. Int J Hyg Environ Health 221:609-615
Neier, K; Cheatham, D; Bedrosian, L D et al. (2018) Perinatal exposures to phthalates and phthalate mixtures result in sex-specific effects on body weight, organ weights and intracisternal A-particle (IAP) DNA methylation in weanling mice. J Dev Orig Health Dis :1-12
Perng, Wei; Baek, Jonggyu; Zhou, Christina W et al. (2018) Associations of the infancy body mass index peak with anthropometry and cardiometabolic risk in Mexican adolescents. Ann Hum Biol :1-9
Veiga-Lopez, Almudena; Pu, Yong; Gingrich, Jeremy et al. (2018) Obesogenic Endocrine Disrupting Chemicals: Identifying Knowledge Gaps. Trends Endocrinol Metab 29:607-625

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