Abstract

The core serves purposes of general utility and will continue immortalizing cell lines by EB virus transformation from blood samples received from other projects; when necessary, it will provide cytogenetic localization of probes by somatic cell analysis and by """"""""in situ"""""""" hybridizations. The computer work related to linkage data will be carried out in the CORE; and new computer programs, the testing by computer simulation of new methods and the statistical support to investigators of the program project, will be mostly done in this group. The new automated instruments now being developed will be operated and maintained by the CORE. Among these is foreseen the acquisition of an automatic thermocycling reactor for PCR (polymerase chain reaction). There is also partial access to an automatic DNA extractor.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM028428-15
Application #
5212069
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Jobin, Matthew J; Mountain, Joanna L (2008) REJECTOR: software for population history inference from genetic data via a rejection algorithm. Bioinformatics 24:2936-7
Henn, Brenna M; Gignoux, Christopher; Lin, Alice A et al. (2008) Y-chromosomal evidence of a pastoralist migration through Tanzania to southern Africa. Proc Natl Acad Sci U S A 105:10693-8
David, Lior; Rosenberg, Noah A; Lavi, Uri et al. (2007) Genetic diversity and population structure inferred from the partially duplicated genome of domesticated carp, Cyprinus carpio L. Genet Sel Evol 39:319-40
Tishkoff, Sarah A; Gonder, Mary Katherine; Henn, Brenna M et al. (2007) History of click-speaking populations of Africa inferred from mtDNA and Y chromosome genetic variation. Mol Biol Evol 24:2180-95
Gross, Eva; Holzl, Georg; Arnold, Norbert et al. (2007) Allelic loss analysis by denaturing high-performance liquid chromatography and electrospray ionization mass spectrometry. Hum Mutat 28:303-11
Sella, Guy; Ardell, David H (2006) The coevolution of genes and genetic codes: Crick's frozen accident revisited. J Mol Evol 63:297-313
Sutton, Wesley K; Knight, Alec; Underhill, Peter A et al. (2006) Toward resolution of the debate regarding purported crypto-Jews in a Spanish-American population: evidence from the Y chromosome. Ann Hum Biol 33:100-11
Greely, Henry T; Riordan, Daniel P; Garrison, Nanibaa' A et al. (2006) Family ties: the use of DNA offender databases to catch offenders' kin. J Law Med Ethics 34:248-62
Kivisild, Toomas; Shen, Peidong; Wall, Dennis P et al. (2006) The role of selection in the evolution of human mitochondrial genomes. Genetics 172:373-87
Belle, Elise M S; Ramakrishnan, Uma; Mountain, Joanna L et al. (2006) Serial coalescent simulations suggest a weak genealogical relationship between Etruscans and modern Tuscans. Proc Natl Acad Sci U S A 103:8012-7

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