Core - Monoclonal Antibody Facility

Ulevitch, Richard J.

Abstract

The core proposal is a request to fund a central monoclonal antibody facility at Scripps Clinic and Research Foundation, to provide travel funds for travel between San Diego and Seattle, and to support a Clinic Coordinator at the University of Washington, Harborview Medical Center.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Research Program Projects (P01)
• Project #: 1P01GM037696-01
• Application #: 3941967
• Support Year: 1
• Fiscal Year: 1987

Institution

• Name: Scripps Research Institute
• City: San Diego
• State: CA
• Country: United States
• Zip Code: 92037

Publications

Tanino, Yoshinori; Chang, Mary Y; Wang, Xintao et al. (2012) Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide. Am J Respir Cell Mol Biol 47:196-202

Manukyan, Maria; Nalbant, Perihan; Luxen, Sylvia et al. (2009) RhoA GTPase activation by TLR2 and TLR3 ligands: connecting via Src to NF-kappa B. J Immunol 182:3522-9

Kurahashi, Kiyoyasu; Sawa, Teiji; Ota, Maria et al. (2009) Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol 296:L198-209

Lu, Miao; Lin, Su-Chang; Huang, Yihua et al. (2007) XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Mol Cell 26:689-702

Lombardo, Eleuterio; Alvarez-Barrientos, Alberto; Maroto, Beatriz et al. (2007) TLR4-mediated survival of macrophages is MyD88 dependent and requires TNF-alpha autocrine signalling. J Immunol 178:3731-9

da Silva Correia, J; Miranda, Y; Leonard, N et al. (2007) Regulation of Nod1-mediated signaling pathways. Cell Death Differ 14:830-9

Kang, Young Jun; Kim, Sung Ouk; Shimada, Shigeki et al. (2007) Cell surface 4-1BBL mediates sequential signaling pathways 'downstream'of TLR and is required for sustained TNF production in macrophages. Nat Immunol 8:601-9

Kravchenko, Vladimir V; Kaufmann, Gunnar F; Mathison, John C et al. (2006) N-(3-oxo-acyl)homoserine lactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways. J Biol Chem 281:28822-30

Ruse, Monica; Knaus, Ulla G (2006) New players in TLR-mediated innate immunity: PI3K and small Rho GTPases. Immunol Res 34:33-48

Martyn, Kendra D; Frederick, Linda M; von Loehneysen, Katharina et al. (2006) Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal 18:69-82