Abstract

Biological Testing Core. The Biological Testing Core facility will provide the resources to perform behavioral assays and ligand binding assays for the compounds synthesized in the Program. It includes support for the individuals who performs the assays, and supplies for this effort.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM047969-08
Application #
6204243
Study Section
Project Start
1999-08-01
Project End
2000-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Budelier, Melissa M; Cheng, Wayland W L; Bergdoll, Lucie et al. (2017) Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1. J Biol Chem 292:9294-9304
Jiang, Xiaoping; Shu, Hong-Jin; Krishnan, Kathiresan et al. (2016) A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition. Neuropharmacology 108:193-206
Zhou, Yu; Xia, Xiao-Ming; Lingle, Christopher J (2015) Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implications. Proc Natl Acad Sci U S A 112:5237-42
Li, Ping; Akk, Gustav (2015) Synaptic-type ?1?2?2L GABAA receptors produce large persistent currents in the presence of ambient GABA and anesthetic drugs. Mol Pharmacol 87:776-81
Drews, A; Mohr, F; Rizun, O et al. (2014) Structural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels. Br J Pharmacol 171:1019-32
Qian, Mingxing; Krishnan, Kathiresan; Kudova, Eva et al. (2014) Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of ?-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone. J Med Chem 57:171-90
Li, P; Bracamontes, J R; Manion, B D et al. (2014) The neurosteroid 5?-pregnan-3?-ol-20-one enhances actions of etomidate as a positive allosteric modulator of ?1?2?2L GABAA receptors. Br J Pharmacol 171:5446-57
Eaton, Megan M; Bracamontes, John; Shu, Hong-Jin et al. (2014) ?-aminobutyric acid type A ?4, ?2, and ? subunits assemble to produce more than one functionally distinct receptor type. Mol Pharmacol 86:647-56
Bracamontes, John R; Li, Ping; Akk, Gustav et al. (2014) Mutations in the main cytoplasmic loop of the GABA(A) receptor ?4 and ? subunits have opposite effects on surface expression. Mol Pharmacol 86:20-7
Zorumski, Charles F; Mennerick, Steven; Izumi, Yukitoshi (2014) Acute and chronic effects of ethanol on learning-related synaptic plasticity. Alcohol 48:1-17

Showing the most recent 10 out of 193 publications