Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
3P01GM058448-03S1
Application #
6443404
Study Section
Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
3
Fiscal Year
2001
Total Cost
$131,647
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Ziemba, Alexis M; Szabo, Andrea; Pierce, David W et al. (2018) Alphaxalone Binds in Inner Transmembrane ?+-?- Interfaces of ?1?3?2 ?-Aminobutyric Acid Type A Receptors. Anesthesiology 128:338-351
Forman, Stuart A (2018) Combining Mutations and Electrophysiology to Map Anesthetic Sites on Ligand-Gated Ion Channels. Methods Enzymol 602:369-389
Woll, Kellie A; Zhou, Xiaojuan; Bhanu, Natarajan V et al. (2018) Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors. FASEB J 32:4172-4189
McGrath, Megan; Yu, Zhiyi; Jayakar, Selwyn S et al. (2018) Etomidate and Etomidate Analog Binding and Positive Modulation of ?-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect. Anesthesiology 129:959-969
Feng, Hua-Jun; Forman, Stuart A (2018) Comparison of ??? and ??? GABAA receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacol Res 133:289-300
McGrath, Megan; Ma, Celena; Raines, Douglas E (2018) Dimethoxy-etomidate: A Nonhypnotic Etomidate Analog that Potently Inhibits Steroidogenesis. J Pharmacol Exp Ther 364:229-237
Zhou, Xiaojuan; Desai, Rooma; Zhang, Yinghui et al. (2018) High-level production and purification in a functional state of an extrasynaptic gamma-aminobutyric acid type A receptor containing ?4?3? subunits. PLoS One 13:e0191583
Ma, Celena; Pejo, Ervin; McGrath, Megan et al. (2017) Competitive Antagonism of Anesthetic Action at the ?-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy. Anesthesiology 127:824-837
Jounaidi, Youssef; Cotten, Joseph F; Miller, Keith W et al. (2017) Tethering IL2 to Its Receptor IL2R? Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells. Cancer Res 77:5938-5951
Yu, Zhiyi; Cohen, Jonathan B (2017) Enantiomeric barbiturates bind distinct inter- and intrasubunit binding sites in a nicotinic acetylcholine receptor (nAChR). J Biol Chem 292:17258-17271

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