Abstract

Annotation and Genomics Core work will be the focus of this project (Project 2) with a subcontract to Oregon Health Sciences University (OHSU; M. Sachs). The archival-quality sequence of the Neurospora genome was completed at Whitehead Institute/MIT Center for Genome Research (WICGR), and automated annotation is ongoing here, so this work is a natural extension of ongoing projects. At present, OHSU is providing liaison with the Neurospora community in terms of coordinating the genomics with the genetics map and the existing Neurospora compendium of genes and phenotypes.
Aims of this project will be to (1) build a platform for electronically capturing community feedback and data about the existing annotation (""""""""gene calls""""""""), (2) building and maintaining a database to capture and display information about phenotypes resulting from gene knock-outs and disruptions, and (3) utilizing data from ongoing EST analyses refine the gene structures.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
1P01GM068087-01A1
Application #
6958175
Study Section
Special Emphasis Panel (ZRG1-GEN (40))
Project Start
2004-04-01
Project End
2009-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
1
Fiscal Year
2004
Total Cost
$468,535
Indirect Cost

  Institution

Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755

  Publications

Fischer, Monika S; Wu, Vincent W; Lee, Ji E et al. (2018) Regulation of Cell-to-Cell Communication and Cell Wall Integrity by a Network of MAP Kinase Pathways and Transcription Factors in Neurospora crassa. Genetics 209:489-506
Serrano, Antonio; Illgen, Julia; Brandt, Ulrike et al. (2018) Spatio-temporal MAPK dynamics mediate cell behavior coordination during fungal somatic cell fusion. J Cell Sci 131:
Qiu, Rongde; Zhang, Jun; Xiang, Xin (2018) p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation. J Biol Chem 293:15606-15619
Heller, Jens; Clavé, Corinne; Gladieux, Pierre et al. (2018) NLR surveillance of essential SEC-9 SNARE proteins induces programmed cell death upon allorecognition in filamentous fungi. Proc Natl Acad Sci U S A 115:E2292-E2301
Wang, Zheng; Wang, Junrui; Li, Ning et al. (2018) Light sensing by opsins and fungal ecology: NOP-1 modulates entry into sexual reproduction in response to environmental cues. Mol Ecol 27:216-232
De Souza, Colin P; Hashmi, Shahr B; Hage, Natalie et al. (2017) Location and functional analysis of the Aspergillus nidulans Aurora kinase confirm mitotic functions and suggest non-mitotic roles. Fungal Genet Biol 103:1-15
Decker, Logan M; Xiao, Hua; Boone, Erin C et al. (2017) The Nuclear Cap-Binding Complex Mediates Meiotic Silencing by Unpaired DNA. G3 (Bethesda) 7:1149-1155
Samarajeewa, Dilini A; Manitchotpisit, Pennapa; Henderson, Miranda et al. (2017) An RNA Recognition Motif-Containing Protein Functions in Meiotic Silencing by Unpaired DNA. G3 (Bethesda) 7:2871-2882
Havlik, David; Brandt, Ulrike; Bohle, Kathrin et al. (2017) Establishment of Neurospora crassa as a host for heterologous protein production using a human antibody fragment as a model product. Microb Cell Fact 16:128
Ivanov, Ivaylo P; Wei, Jiajie; Caster, Stephen Z et al. (2017) Translation Initiation from Conserved Non-AUG Codons Provides Additional Layers of Regulation and Coding Capacity. MBio 8:

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