The Administrative Core will perform three principal roles. First, it will provide an administrattive frameworkfor the Program. This will involve clerical and logistical support for the Projects and Cores in addition toproviding financial oversight. The Core will coordinate activities within the Program including the seminarseries, journal clubs, the annual scientific retreat, visits by members of advisory boards and collaboratingscientists. A scientific advisory board will oversee the scientific activities of the Program, including themanagement of the Pilot Project and Training Programs. The Core will asist, where possible, the ExecutiveComittee, composed of the Program and Core Directors. This committee will work with the Program'sDirector, Dr. Stephen Dalton, to manage overall activities, to make decisions regarding the Pilot Project andTraining programs and, to evaluate the overall direction and goals of the Program. Dr. Dalton will workclosely with the Core's Administrative Manager to ensure that the Program is coordinated and functionsefficiently.A second role of the Core, will be to administer the Pilot Project Program which will consist of three projects,to be funded annually with awards of $45,000/project. The Core will solicit applications from investigators inthe Southeast region with an objective to stimulate innovative hESC research in the region. The Program istargeted towards new investigtaors to the field. The Administrative Core will manage the selection andadministration of the Pilot Projects and will coordinate activities between awardees and other components ofthe Program.A third role for the Core will be to manage and promote interactions between the Program and theSoutheastern hESC community, including technology and reagent transfer, collaborative initiatives. TheCore will establish mechanisms to promote interactions with the Southeastern scientific community includingweb-based resources.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
1P01GM085354-01
Application #
7538048
Study Section
Special Emphasis Panel (ZGM1-GDB-8 (SC))
Project Start
Project End
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
1
Fiscal Year
2008
Total Cost
$272,500
Indirect Cost
Name
University of Georgia
Department
Type
DUNS #
004315578
City
Athens
State
GA
Country
United States
Zip Code
30602
Sima, Jiao; Bartlett, Daniel A; Gordon, Molly R et al. (2018) Bacterial artificial chromosomes establish replication timing and sub-nuclear compartment de novo as extra-chromosomal vectors. Nucleic Acids Res 46:1810-1820
Singh, Amar M; Dalton, Stephen (2018) What Can 'Brown-ing' Do For You? Trends Endocrinol Metab 29:349-359
Dixon, Jesse R; Xu, Jie; Dileep, Vishnu et al. (2018) Integrative detection and analysis of structural variation in cancer genomes. Nat Genet 50:1388-1398
Xu, Chenhuan; Corces, Victor G (2018) Genome-Wide Mapping of Protein-DNA Interactions on Nascent Chromatin. Methods Mol Biol 1766:231-238
Dileep, Vishnu; Gilbert, David M (2018) Single-cell replication profiling to measure stochastic variation in mammalian replication timing. Nat Commun 9:427
Colunga, Thomas; Dalton, Stephen (2018) Building Blood Vessels with Vascular Progenitor Cells. Trends Mol Med 24:630-641
Wang, Tao; Holt, Matthew V; Young, Nicolas L (2018) The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance. Epigenetics Chromatin 11:29
Xu, Chenhuan; Corces, Victor G (2018) Nascent DNA methylome mapping reveals inheritance of hemimethylation at CTCF/cohesin sites. Science 359:1166-1170
Marchal, Claire; Sasaki, Takayo; Vera, Daniel et al. (2018) Genome-wide analysis of replication timing by next-generation sequencing with E/L Repli-seq. Nat Protoc 13:819-839
Rivera-Mulia, Juan Carlos; Schwerer, Hélène; Besnard, Emilie et al. (2018) Cellular senescence induces replication stress with almost no affect on DNA replication timing. Cell Cycle 17:1667-1681

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