Abstract

This project will examine the role of dopamine in neurogenesis and neuronal migration, and determine of prenatal cocaine exposure, which is known to affect the aminergic systems, alters those processes. The investigators will study mice in vivo and in vitro to determine the role of dopamine in brain development, and on the consequences of disruption of the dopaminergic system by prenatal cocaine exposure.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
2P01HD005515-32
Application #
6482736
Study Section
National Institute of Child Health and Human Development Initial Review Group (CHHD)
Project Start
1977-09-01
Project End
2005-11-30
Budget Start
Budget End
Support Year
32
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
University of Massachusetts Medical School Worcester
Department
Type
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655

  Publications

Crandall, James E; Goodman, Timothy; McCarthy, Deirdre M et al. (2011) Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex. J Neurochem 119:723-35
Crandall, James E; McCarthy, Deirdre M; Araki, Kiyomi Y et al. (2007) Dopamine receptor activation modulates GABA neuron migration from the basal forebrain to the cerebral cortex. J Neurosci 27:3813-22
Wang, Junning; Tse, Sze-Wah; Andreadis, Athena (2007) Tau exon 6 is regulated by an intricate interplay of trans factors and cis elements, including multiple branch points. J Neurochem 100:437-45
Araki, Kiyomi Y; Fujimura, Satoshi; MacDonald, Marcy E et al. (2006) Characterization of mouse striatal precursor cell lines expressing functional dopamine receptors. Dev Neurosci 28:518-27
Leroy, Olivier; Wang, Junning; Maurage, Claude-Alain et al. (2006) Brain-specific change in alternative splicing of Tau exon 6 in myotonic dystrophy type 1. Biochim Biophys Acta 1762:460-7
Leroy, Olivier; Dhaenens, Claire-Marie; Schraen-Maschke, Suzanna et al. (2006) ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I. J Neurosci Res 84:852-9
Qu, Qiang; Crandall, James E; Luo, Tuanlian et al. (2006) Defects in tangential neuronal migration of pontine nuclei neurons in the Largemyd mouse are associated with stalled migration in the ventrolateral hindbrain. Eur J Neurosci 23:2877-86
McCaffery, Peter; Zhang, Jinghua; Crandall, James E (2006) Retinoic acid signaling and function in the adult hippocampus. J Neurobiol 66:780-91
Qu, Qiang; Smith, Frances I (2005) Neuronal migration defects in cerebellum of the Largemyd mouse are associated with disruptions in Bergmann glia organization and delayed migration of granule neurons. Cerebellum 4:261-70
McCaffery, Peter; Deutsch, Curtis K (2005) Macrocephaly and the control of brain growth in autistic disorders. Prog Neurobiol 77:38-56

Showing the most recent 10 out of 180 publications