Sources of Maternal and Fetal CMV Infection

Pass, Robert F.

Abstract

This proposal will test the hypothesis that young children are an important source of CMV infection for their mothers and that maternal infection acquired from a child by a pregnant women can result in fetal infection. Our extensive work in CMV epidemiology, particularly recent studies of transmission of CMV among children and to their parents, coupled with knowledge that virtually nothing is known about sources of maternal CMV infection , led to formulation of this hypothesis and our plan for addressing it. Recognizing existing epidemiologic data that supports a role for sexual transmission, we also plan to evaluate the potential importance of this mechanism of maternal and fetal infection through a study of mothers of children with congenital CMV infection, utilizing a case-control design, and through longitudinal study of sexually active adolescents.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
• Type: Research Program Projects (P01)
• Project #: 5P01HD010699-15
• Application #: 3857358
• Support Year: 15
• Fiscal Year: 1991

Institution

• Name: University of Alabama Birmingham
• DUNS #: 004514360
• City: Birmingham
• State: AL
• Country: United States
• Zip Code: 35294

Publications

Pinninti, Swetha G; Rodgers, Mackenzie D; Novak, Zdenek et al. (2016) Clinical Predictors of Sensorineural Hearing Loss and Cognitive Outcome in Infants with Symptomatic Congenital Cytomegalovirus Infection. Pediatr Infect Dis J 35:924-6

Dreher, A Mackenzie; Arora, Nitin; Fowler, Karen B et al. (2014) Spectrum of disease and outcome in children with symptomatic congenital cytomegalovirus infection. J Pediatr 164:855-9

Rosenthal, Lauren Stancik; Fowler, Karen B; Boppana, Suresh B et al. (2009) Cytomegalovirus shedding and delayed sensorineural hearing loss: results from longitudinal follow-up of children with congenital infection. Pediatr Infect Dis J 28:515-20

Ross, Shannon A; Novak, Zdenek; Fowler, Karen B et al. (2009) Cytomegalovirus blood viral load and hearing loss in young children with congenital infection. Pediatr Infect Dis J 28:588-92

Ross, Shannon A; Novak, Zdenek; Kumbla, Rekha A et al. (2007) GJB2 and GJB6 mutations in children with congenital cytomegalovirus infection. Pediatr Res 61:687-91

Ross, Shannon A; Fowler, Karen B; Ashrith, Guha et al. (2006) Hearing loss in children with congenital cytomegalovirus infection born to mothers with preexisting immunity. J Pediatr 148:332-6

Pass, Robert F; Fowler, Karen B; Boppana, Suresh B et al. (2006) Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcome. J Clin Virol 35:216-20

Fowler, Karen B; Boppana, Suresh B (2006) Congenital cytomegalovirus (CMV) infection and hearing deficit. J Clin Virol 35:226-31

Fowler, Karen B; Pass, Robert F (2006) Risk factors for congenital cytomegalovirus infection in the offspring of young women: exposure to young children and recent onset of sexual activity. Pediatrics 118:e286-92

Pryor, Shannon P; Demmler, Gail J; Madeo, Anne C et al. (2005) Investigation of the role of congenital cytomegalovirus infection in the etiology of enlarged vestibular aqueducts. Arch Otolaryngol Head Neck Surg 131:388-92