Abstract

The Lesion Induction Core is designed to support all projects requiring animals with induced developmental malformations of the cortex. Thus all experiments from all projects that require mice or rats with either induced microgyria Or induced molecular layer ectopias will be generated by this core. This centralized core devoted to the induction of anomalies will help to ensure uniform lesions for all experiments in all projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
2P01HD020806-12
Application #
6272093
Study Section
Project Start
1998-04-01
Project End
1999-03-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
12
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Chen, Fuyi; Becker, Albert; LoTurco, Joseph (2016) Overview of Transgenic Glioblastoma and Oligoastrocytoma CNS Models and Their Utility in Drug Discovery. Curr Protoc Pharmacol 72:14.37.1-12
Truong, Dongnhu T; Rendall, Amanda R; Rosen, Glenn D et al. (2015) Morphometric changes in subcortical structures of the central auditory pathway in mice with bilateral nodular heterotopia. Behav Brain Res 282:61-9
Che, Alicia; Girgenti, Matthew J; LoTurco, Joseph (2014) The dyslexia-associated gene DCDC2 is required for spike-timing precision in mouse neocortex. Biol Psychiatry 76:387-96
Siddiqi, Faez; Chen, Fuyi; Aron, Abraham W et al. (2014) Fate mapping by piggyBac transposase reveals that neocortical GLAST+ progenitors generate more astrocytes than Nestin+ progenitors in rat neocortex. Cereb Cortex 24:508-20
Fitch, R Holy; Alexander, Michelle L; Threlkeld, Steven W (2013) Early neural disruption and auditory processing outcomes in rodent models: implications for developmental language disability. Front Syst Neurosci 7:58
Truong, Dongnhu T; Bonet, Ashley; Rendall, Amanda R et al. (2013) A behavioral evaluation of sex differences in a mouse model of severe neuronal migration disorder. PLoS One 8:e73144
Tarkar, Aarti; Loges, Niki T; Slagle, Christopher E et al. (2013) DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nat Genet 45:995-1003
Chen, Fuyi; LoTurco, Joseph (2012) A method for stable transgenesis of radial glia lineage in rat neocortex by piggyBac mediated transposition. J Neurosci Methods 207:172-80
Maher, Brady J; LoTurco, Joseph J (2012) Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses. PLoS One 7:e34053
Threlkeld, Steven W; Hill, Courtney A; Szalkowski, Caitlin E et al. (2012) Effects of test experience and neocortical microgyria on spatial and non-spatial learning in rats. Behav Brain Res 235:130-5

Showing the most recent 10 out of 121 publications