Continuation is proposed for three highly interrelated projects: (a) a longitudinal behavioral study of normal, reading impaired, and """"""""at risk"""""""" samples which had been started in 1st grade, third grade, and kindergarten, respectively; (b) a family study of adult dyslexics (defined by childhood psychometrics), including their spouses, siblings, parents, and children, and using behavioral measurement of the phenotype for all subjects and electrophysiological measurement of the phenotype for probands and their children; and (c) an integrated multidimensional physiological and anatomical study of the dyslexic phenotype---using blood flow (rCBF), event related potentials (ERP), positron emission tomography (PET), and magnetic resonance imaging (MRI). These studies are intended to clarify: (a) the longitudinal course of normal and impaired reading, and the differentiation of these courses from each other, including the demonstration of phenotypic markers of emerging dyslexia distinct from attention deficit disorder, low intelligence, and related conditions, and the possible intra-linguistic subtyping of the dyslexic phenotype; (b) the familial transmission patterns of the phenotype and its component processes and related comorbid disorders such as ADHD. (c) converging evidence for an anatomical (temporal planum; and physiological (left temporal, left angular gyrus, left caudate) deficit as characterizing the dyslexic phenotype.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD021887-13
Application #
6329879
Study Section
Special Emphasis Panel (ZHD1-DRG-D (FW))
Program Officer
Lyon, Reid G
Project Start
1986-08-01
Project End
2003-11-30
Budget Start
2000-12-01
Budget End
2001-11-30
Support Year
13
Fiscal Year
2001
Total Cost
$1,066,888
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Neurology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Casanova, Ramon; Srikanth, Ryali; Baer, Aaron et al. (2007) Biological parametric mapping: A statistical toolbox for multimodality brain image analysis. Neuroimage 34:137-43
Chait, Maria; Eden, Guinevere; Poeppel, David et al. (2007) Delayed detection of tonal targets in background noise in dyslexia. Brain Lang 102:80-90
Goldston, David B; Walsh, Adam; Mayfield Arnold, Elizabeth et al. (2007) Reading problems, psychiatric disorders, and functional impairment from mid- to late adolescence. J Am Acad Child Adolesc Psychiatry 46:25-32
Daniel, Stephanie S; Walsh, Adam K; Goldston, David B et al. (2006) Suicidality, school dropout, and reading problems among adolescents. J Learn Disabil 39:507-14
Wood, Frank B; Hill, Deborah F; Meyer, Marianne S et al. (2005) Predictive assessment of reading. Ann Dyslexia 55:193-216
Hairston, W David; Burdette, Jonathan H; Flowers, D Lynn et al. (2005) Altered temporal profile of visual-auditory multisensory interactions in dyslexia. Exp Brain Res 166:474-80
Arnold, Elizabeth Mayfield; Goldston, David B; Walsh, Adam K et al. (2005) Severity of emotional and behavioral problems among poor and typical readers. J Abnorm Child Psychol 33:205-17
Flowers, D L; Jones, K; Noble, K et al. (2004) Attention to single letters activates left extrastriate cortex. Neuroimage 21:829-39
Eden, Guinevere F; Jones, Karen M; Cappell, Katherine et al. (2004) Neural changes following remediation in adult developmental dyslexia. Neuron 44:411-22
Grigorenko, Elena L; Wood, Frank B; Golovyan, Lina et al. (2003) Continuing the search for dyslexia genes on 6p. Am J Med Genet B Neuropsychiatr Genet 118B:89-98

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