Abstract

The goal of this project is to study the NMDA receptor in development and developmental plasticity. We will examine the development of the NMDA receptor complex in olfactory and hippocampal circuits in relationship to the critical periods for olfactory learning. We will also pursue studies on the action of NMDA antagonists in early olfactory glomerular plasticity. This will consist of identifying the minimal period of administration, the use of newly developed and highly specific analogues, and the direct administration of compounds into the brain. Collaborative projects are proposed to investigate the relationship between NMDA receptor activation, other neurotransmitter systems, and early learning.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
1P01HD024236-01A1
Application #
3899133
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Type
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Neve, R L; Geller, A I (1999) Genetic analysis of neuronal physiology with defective herpes simplex virus vectors. Adv Neurol 79:1027-32
Song, S; Wang, Y; Bak, S Y et al. (1998) Modulation of rat rotational behavior by direct gene transfer of constitutively active protein kinase C into nigrostriatal neurons. J Neurosci 18:4119-32
Johnson, B A; Woo, C C; Leon, M (1998) Spatial coding of odorant features in the glomerular layer of the rat olfactory bulb. J Comp Neurol 393:457-71
Ripellino, J A; Neve, R L; Howe, J R (1998) Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum. Neuroscience 82:485-97
Neve, R L; Howe, J R; Hong, S et al. (1997) Introduction of the glutamate receptor subunit 1 into motor neurons in vitro and in vivo using a recombinant herpes simplex virus. Neuroscience 79:435-47
McCollum, J F; Woo, C C; Leon, M (1997) Granule and mitral cell densities are unchanged following early olfactory preference training. Brain Res Dev Brain Res 99:118-20
Song, S; Wang, Y; Bak, S Y et al. (1997) An HSV-1 vector containing the rat tyrosine hydroxylase promoter enhances both long-term and cell type-specific expression in the midbrain. J Neurochem 68:1792-803
Tsai, K C; Cansino, V V; Kohn, D T et al. (1997) Post-transcriptional regulation of the GAP-43 gene by specific sequences in the 3' untranslated region of the mRNA. J Neurosci 17:1950-8
Hess, U S; Gall, C M; Granger, R et al. (1997) Differential patterns of c-fos mRNA expression in amygdala during successive stages of odor discrimination learning. Learn Mem 4:262-83
Hartley, D M; Neve, R L; Bryan, J et al. (1996) Expression of the calcium-binding protein, parvalbumin, in cultured cortical neurons using a HSV-1 vector system enhances NMDA neurotoxicity. Brain Res Mol Brain Res 40:285-96

Showing the most recent 10 out of 53 publications