Program Project support is requested for a coordinated, multidisciplinary approach to investigate the role of milk-borne hormones and other active biological substances for the neonate. Support is requested for three scientific projects and three cores (Morphological, Animal and Administrative). The three proposed projects deal with the fate and effects of milk-borne peptide hormones and carnitine in the suckling rat. They are: PROJECT 1. Role of Milk-Borne Growth Factors for the Suckling: Their Content and Synthesis. Principal Investigator: O. Koldovsky PROJECT 2. Role of Milk-Borne Growth Factors for the Suckling: Their Effects on the Neonate. Principal Investigator: A.F. Philipps PROJECT 3. Role of Milk-Borne Biological Substances in the Developing Liver. Principal Investigator: R. McCuskey These projects are basic in nature, and the information derived from them will be applicable to a variety of normal and pathological conditions. Studies have demonstrated that some of these substances are absent in infant formulas, but are present in human breast milk, emphasizing the important significance of these proposed studies.
| Sørensen, Karen Kristine; Simon-Santamaria, Jaione; McCuskey, Robert S et al. (2015) Liver Sinusoidal Endothelial Cells. Compr Physiol 5:1751-74 |
| Kling, Pamela J; Willeitner, Andrea; Dvorak, Bohuslav et al. (2008) Enteral erythropoietin and iron stimulate erythropoiesis in suckling rats. J Pediatr Gastroenterol Nutr 46:202-7 |
| McCuskey, Robert S (2008) The hepatic microvascular system in health and its response to toxicants. Anat Rec (Hoboken) 291:661-71 |
| Kling, Pamela J; Taing, K Muy; Dvorak, Bohuslav et al. (2006) Insulin-like growth factor-I stimulates erythropoiesis when administered enterally. Growth Factors 24:218-23 |
| Dvorak, Bohuslav; Halpern, Melissa D; Holubec, Hana et al. (2004) Rat milk decreases necrotizing enterocolitis in a rat model. Adv Exp Med Biol 554:471-3 |
| Dvorak, Bohuslav; Fituch, Camellia C; Williams, Catherine S et al. (2004) Concentrations of epidermal growth factor and transforming growth factor-alpha in preterm milk. Adv Exp Med Biol 554:407-9 |
| Halpern, Melissa D; Dominguez, Jessica A; Dvorakova, Katerina et al. (2003) Ileal cytokine dysregulation in experimental necrotizing enterocolitis is reduced by epidermal growth factor. J Pediatr Gastroenterol Nutr 36:126-33 |
| Halpern, Melissa D; Holubec, Hana; Dominguez, Jessica A et al. (2003) Hepatic inflammatory mediators contribute to intestinal damage in necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 284:G695-702 |
| McCuskey, Robert S; Ekataksin, Wichai; LeBouton, Albert V et al. (2003) Hepatic microvascular development in relation to the morphogenesis of hepatocellular plates in neonatal rats. Anat Rec A Discov Mol Cell Evol Biol 275:1019-30 |
| Dvorak, Bohuslav; Halpern, Melissa D; Holubec, Hana et al. (2003) Maternal milk reduces severity of necrotizing enterocolitis and increases intestinal IL-10 in a neonatal rat model. Pediatr Res 53:426-33 |
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