Abstract

A Program Project will be established in order to support an interactive program of research dedicated to understanding the molecular mechanisms of the cell interactions that control development. The cell interactions controlling cell proliferation will be investigated by a molecular analysis of a cell-proliferation control gene in Drosophila which encodes a cell adhesion molecule, and by studying the relationship between adhesion and proliferation of imaginal disc cells in vitro using a new culture system. Several genes required for the cell interactions that control cell and tissue polarity will be investigated at the genetic and molecular levels in Drosophila. Genes involved in the cell interactions governing head and foot formation in hydra will be isolated and characterized, their expression patterns studied, and their functions investigated in transgenic animals. The Project will support a Research Core Unit for antibody production, confocal microscopy, and image analysis which will be used by all of the component projects. The work will contribute to our understanding of the molecular mechanisms controlling normal development and regeneration as well as the defects in cell interaction mechanisms that underlie birth defects and cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD027173-02
Application #
3097236
Study Section
Maternal and Child Health Research Committee (HDMC)
Project Start
1992-05-01
Project End
1997-04-30
Budget Start
1993-05-01
Budget End
1994-04-30
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Technau, U; Bode, H R (1999) HyBra1, a Brachyury homologue, acts during head formation in Hydra. Development 126:999-1010
Grens, A; Shimizu, H; Hoffmeister, S A et al. (1999) The novel signal peptides, pedibin and Hym-346, lower positional value thereby enhancing foot formation in hydra. Development 126:517-24
Bode, H; Martinez, D; Shenk, M A et al. (1999) Evolution of head development. Biol Bull 196:408-10
Mason, E D; Marsh, J L (1998) Changes in the pattern of twisted gastrulation gene expression among Drosophila species. J Mol Evol 46:180-7
Konrad, K D; Goralski, T J; Mahowald, A P et al. (1998) The gastrulation defective gene of Drosophila melanogaster is a member of the serine protease superfamily. Proc Natl Acad Sci U S A 95:6819-24
Martinez, D E; Dirksen, M L; Bode, P M et al. (1997) Budhead, a fork head/HNF-3 homologue, is expressed during axis formation and head specification in hydra. Dev Biol 192:523-36
Buratovich, M A; Bryant, P J (1997) Enhancement of overgrowth by gene interactions in lethal(2)giant discs imaginal discs from Drosophila melanogaster. Genetics 147:657-70
Heslip, T R; Theisen, H; Walker, H et al. (1997) Shaggy and dishevelled exert opposite effects on Wingless and Decapentaplegic expression and on positional identity in imaginal discs. Development 124:1069-78
Mason, E D; Williams, S; Grotendorst, G R et al. (1997) Combinatorial signaling by Twisted Gastrulation and Decapentaplegic. Mech Dev 64:61-75
Martin, V J; Littlefield, C L; Archer, W E et al. (1997) Embryogenesis in hydra. Biol Bull 192:345-63

Showing the most recent 10 out of 19 publications