The overall goal of this project is to test the hypothesis that oxidative stress plays a pathogenic role in preeclampsia. Dr. Robert's hypothesis is that abnormal placentation leads to relative ischemia and hypoxia, which then contributes to the generation of oxidative stressors in the maternal circulation that damage endothelium and lead to the widespread, multisystemic manifestations of preeclampsia. A second hypothesis is that maternal factors, which vary from woman to woman are important in the expression of the disease. The specific maternal factors to be explored are those that have also been associated with cardiovascular disease in nonpregnant populations; specifically, insulin resistance and dyslipidemia. The longitudinal data will be obtained from nulliparous women early in pregnancy, prior to disease, during disease, and postpartum. Using this strategy, various markers of oxidative stress in plasma/serum will be analyzed maternal and placental tissues will be examined for evidence of free radical induced damage the maternal constitutional factors contributing to oxidative stress will be examined and specific oxidative stressors will be studied such as TNF alpha, iron metabolism and consumption of ascorbate. Finally, the endogenous protective mechanisms against oxidative stress - antioxidants - will be measured.
| Global Pregnancy Collaboration:; Schalekamp-Timmermans, Sarah; Arends, Lidia R et al. (2017) Fetal sex-specific differences in gestational age at delivery in pre-eclampsia: a meta-analysis. Int J Epidemiol 46:632-642 |
| Hux, Vanessa J; Roberts, James M; Okun, Michele L (2017) Allostatic load in early pregnancy is associated with poor sleep quality. Sleep Med 33:85-90 |
| Countouris, Malamo E; Schwarz, Eleanor B; Rossiter, Brianna C et al. (2016) Effects of lactation on postpartum blood pressure among women with gestational hypertension and preeclampsia. Am J Obstet Gynecol 215:241.e1-8 |
| Gandley, Robin E; Althouse, Andrew; Jeyabalan, Arundhathi et al. (2016) Low Soluble Syndecan-1 Precedes Preeclampsia. PLoS One 11:e0157608 |
| Tan, Hong Chang; Roberts, James; Catov, Janet et al. (2015) Mother's pre-pregnancy BMI is an important determinant of adverse cardiometabolic risk in childhood. Pediatr Diabetes 16:419-26 |
| Schmella, Mandy J; Clifton, Rebecca G; Althouse, Andrew D et al. (2015) Uric Acid Determination in Gestational Hypertension: Is it as Effective a Delineator of Risk as Proteinuria in High-Risk Women? Reprod Sci 22:1212-9 |
| Luiza, John W; Gallaher, Marcia J; Powers, Robert W (2015) Urinary cortisol and depression in early pregnancy: role of adiposity and race. BMC Pregnancy Childbirth 15:30 |
| Hux, Vanessa J; Roberts, James M (2015) A potential role for allostatic load in preeclampsia. Matern Child Health J 19:591-7 |
| Hassis, Maria E; Niles, Richard K; Braten, Miles N et al. (2015) Evaluating the effects of preanalytical variables on the stability of the human plasma proteome. Anal Biochem 478:14-22 |
| Catov, Janet M; Abatemarco, Diane; Althouse, Andrew et al. (2015) Patterns of gestational weight gain related to fetal growth among women with overweight and obesity. Obesity (Silver Spring) 23:1071-8 |
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