Abstract

The overall objective of the Neuropathology Core is to prepare and interpret neuropathologic material derived from the various experiments described in Projects and Cores.
Specific aims i nclude: histologic processing of brain specimens for light and electron microscopy, an expert interpretation of neuropathologic alterations arising from cerebral hypoxia-ischemia or status epilepticus. Brains to be studied will include those of developing postnatal rats and rabbits previous subjected to cerebral hypoxia-ischemia or status epilepticus. Brains will be fixed in situ or by perfusion-fixation or immersion using a variety of fixatives. Thereafter, brains will be examined grossly and microscopically, and the extent of damage determined by specific scoring methods. Histologic processing will include those techniques required for paraffin or resin embedding followed by tissue sectioning. A variety of stains will be used to accentuate morphologic alterations. Histologic interpretation will be conducted by the Principal Investigator in collaboration with the Principal Investigators of the individual projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD030704-08
Application #
6484762
Study Section
Project Start
2001-07-01
Project End
2002-06-30
Budget Start
Budget End
Support Year
8
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Type
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033

  Publications

Leroy, Claire; Pierre, Karin; Simpson, Ian A et al. (2011) Temporal changes in mRNA expression of the brain nutrient transporters in the lithium-pilocarpine model of epilepsy in the immature and adult rat. Neurobiol Dis 43:588-97
Sen, Ellora; Basu, Anirban; Willing, Lisa B et al. (2011) Pre-conditioning induces the precocious differentiation of neonatal astrocytes to enhance their neuroprotective properties. ASN Neuro 3:e00062
Simpson, Ian A; Carruthers, Anthony; Vannucci, Susan J (2007) Supply and demand in cerebral energy metabolism: the role of nutrient transporters. J Cereb Blood Flow Metab 27:1766-91
Jin, Yuxuan; Silverman, Ann-Judith; Vannucci, Susan J (2007) Mast cell stabilization limits hypoxic-ischemic brain damage in the immature rat. Dev Neurosci 29:373-84
Kremlev, Sergey G; Roberts, Rebecca L; Palmer, Charles (2007) Minocycline modulates chemokine receptors but not interleukin-10 mRNA expression in hypoxic-ischemic neonatal rat brain. J Neurosci Res 85:2450-9
Zhang, X; Surguladze, N; Slagle-Webb, B et al. (2006) Cellular iron status influences the functional relationship between microglia and oligodendrocytes. Glia 54:795-804
Nehlig, Astrid; Rudolf, Gabrielle; Leroy, Claire et al. (2006) Pentylenetetrazol-induced status epilepticus up-regulates the expression of glucose transporter mRNAs but not proteins in the immature rat brain. Brain Res 1082:32-42
Hurn, Patricia D; Vannucci, Susan J; Hagberg, Henrik (2005) Adult or perinatal brain injury: does sex matter? Stroke 36:193-5
Kremlev, Sergey G; Palmer, Charles (2005) Interleukin-10 inhibits endotoxin-induced pro-inflammatory cytokines in microglial cell cultures. J Neuroimmunol 162:71-80
Basu, Anirban; Lazovic, Jelena; Krady, J Kyle et al. (2005) Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury. J Cereb Blood Flow Metab 25:17-29

Showing the most recent 10 out of 55 publications