Abstract

Introduction. All projects in this proposal will use the administrative core. We will maintain the basic organization of the Center for Perinatal Biology which has developed during the past two decades. This structure has grown out of the close scientific collaboration among the investigators in our group. This overall organization includes the core facilities for administrative and laboratory services, and an objective evaluation of our scientific progress both quarterly and annually. We will administer the program as efficiently as possible, so that the maximum amount of each investigator's time can be devoted to the research per se.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
2P01HD031226-16
Application #
8015758
Study Section
Special Emphasis Panel (ZHD1-DSR-A (LL))
Project Start
2010-08-01
Project End
2015-07-31
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
16
Fiscal Year
2010
Total Cost
$105,084
Indirect Cost

  Institution

Name
Loma Linda University
Department
Type
DUNS #
009656273
City
Loma Linda
State
CA
Country
United States
Zip Code
92350

  Publications

Liu, Taiming; Zhang, Meijuan; Terry, Michael H et al. (2018) Nitrite potentiates the vasodilatory signaling of S-nitrosothiols. Nitric Oxide 75:60-69
Pearce, William J (2018) Fetal Cerebrovascular Maturation: Effects of Hypoxia. Semin Pediatr Neurol 28:17-28
Pearce, W J (2018) A path well travelled may lead to better stroke recovery. Acta Physiol (Oxf) 223:e13061
Vargas, Vladimir E; Myers, Dean A; Kaushal, Kanchan M et al. (2018) Expression of StAR and Key Genes Regulating Cortisol Biosynthesis in Near Term Ovine Fetal Adrenocortical Cells: Effects of Long-Term Hypoxia. Reprod Sci 25:230-238
Chuang, Tsai-Der; Sakurai, Reiko; Gong, Ming et al. (2018) Role of miR-29 in Mediating Offspring Lung Phenotype in a Rodent Model of Intrauterine Growth Restriction. Am J Physiol Regul Integr Comp Physiol :
Liu, Taiming; Schroeder, Hobe J; Wilson, Sean M et al. (2016) Local and systemic vasodilatory effects of low molecular weight S-nitrosothiols. Free Radic Biol Med 91:215-23
Myers, Dean A; Singleton, Krista; Kenkel, Christy et al. (2016) Gestational hypoxia modulates expression of corticotropin-releasing hormone and arginine vasopressin in the paraventricular nucleus in the ovine fetus. Physiol Rep 4:
Liu, Taiming; Schroeder, Hobe J; Zhang, Meijuan et al. (2016) S-nitrosothiols dilate the mesenteric artery more potently than the femoral artery by a cGMP and L-type calcium channel-dependent mechanism. Nitric Oxide 58:20-7
Vrancken, Kurt; Schroeder, Hobe J; Longo, Lawrence D et al. (2016) Postprandial lipids accelerate and redirect nitric oxide consumption in plasma. Nitric Oxide 55-56:70-81
Hu, Xiang-Qun; Huang, Xiaohui; Xiao, Daliao et al. (2016) Direct effect of chronic hypoxia in suppressing large conductance Ca(2+)-activated K(+) channel activity in ovine uterine arteries via increasing oxidative stress. J Physiol 594:343-56

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