This Core B has primary responsibility for coordination and tracking of subjects for the Program Project investigations it Core B also has responsibility for acquisition of data collected during induction, for entry of this data into the Program Project Database/Data Archives, and for scheduling and tracking the progress of data acquisition and analysis in general across all projects. This Core is organized into a set of service- based subcores which provide cost-efficient and centralized resource services-based subcores which provide cost-efficient an centralized resource services to the five Projects. The subcores are as follows: (1) Induction/Screening Subcore will perform the screening of all human subjects to the Program Project, which includes gathering of medical, behavioral, and background records relevant to induction and application of inclusionary/exclusionary criteria; (2) Behavioral Diagnostics Subcore will be responsible for acquisition and analysis of behavioral data associated with induciton, including standardized tests of intelligence for matching and measures of affective functioning and home environment for matching and application of inclusionary/exclusionary criteria; (3) Neuroimaging/ERP Subcore will be responsible for coordinating the acquisition of ERP and MRI data for Project II and Project III studies; (4) Brain Autopsy Subcore will coordinate brain removal, tissue acquisition for genetic analyses (in coordination with Genetic Samples Subcore and Project III), brain fixation, MRI (in coordination with Neuroimaging Subcore and Project II), and transport to the Project IV experimental laboratory for detailed cytoarchitectonic analysis; (5) Genetic Samples Subcore will obtain blood samples from all WMS subjects and their parents, enter pertinent information about the sample donors to the database and assign a pseudonym, mail the blood sample for transformation and storage, and transmit data and DNA samples to Project V. Across all subcores, Core B will be responsible for organizing an efficient schedule of subject interaction with Program Project personnel, allowing for collection of all necessary data. It will also track data after collection and processing to ensure timely and accurate entry to the Project Database/Data Archives, and to ensure efficient flow of data among Projects and between projects and cores.

Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Chailangkarn, Thanathom; Noree, Chalongrat; Muotri, Alysson R (2018) The contribution of GTF2I haploinsufficiency to Williams syndrome. Mol Cell Probes 40:45-51
Ng, Rowena; Lai, Philip; Brown, Timothy T et al. (2018) Neuroanatomical correlates of emotion-processing in children with unilateral brain lesion: A preliminary study of limbic system organization. Soc Neurosci 13:688-700
Griesi-Oliveira, Karina; Suzuki, Angela May; Muotri, Alysson Renato (2017) TRPC Channels and Mental Disorders. Adv Exp Med Biol 976:137-148
Herai, Roberto H; Negraes, Priscilla D; Muotri, Alysson R (2017) Evidence of nuclei-encoded spliceosome mediating splicing of mitochondrial RNA. Hum Mol Genet 26:2472-2479
Ng, Rowena; Brown, Timothy T; Järvinen, Anna M et al. (2016) Structural integrity of the limbic-prefrontal connection: Neuropathological correlates of anxiety in Williams syndrome. Soc Neurosci 11:187-92
Ng, Rowena; Brown, Timothy T; Erhart, Matthew et al. (2016) Morphological differences in the mirror neuron system in Williams syndrome. Soc Neurosci 11:277-88
Green, Tamar; Fierro, Kyle C; Raman, Mira M et al. (2016) Surface-based morphometry reveals distinct cortical thickness and surface area profiles in Williams syndrome. Am J Med Genet B Neuropsychiatr Genet 171B:402-13
Järvinen, Anna; Ng, Rowena; Crivelli, Davide et al. (2015) Relations between social-perceptual ability in multi- and unisensory contexts, autonomic reactivity, and social functioning in individuals with Williams syndrome. Neuropsychologia 73:127-40
Järvinen, Anna; Ng, Rowena; Bellugi, Ursula (2015) Autonomic response to approachability characteristics, approach behavior, and social functioning in Williams syndrome. Neuropsychologia 78:159-70
Ng, Rowena; Fishman, Inna; Bellugi, Ursula (2015) Frontal asymmetry index in Williams syndrome: Evidence for altered emotional brain circuitry? Soc Neurosci 10:366-75

Showing the most recent 10 out of 92 publications