Abstract

The Clinical Core will be responsible for the recruitment, medical assessment, and medical management of study patients. The Department of Physical Medicine and Rehabilitation at the University of Michigan Medical Center has well established treatment programs for, and ready access to, patients with spinal cord injury and brachial plexus injury. The Clinical Core will also administer and monitor the response of patients with chronic pain to antidepressant and anticonvulsant medication used to treat their chronic neuropathic pain. The Clinical Core will provide information regarding the clinical status of patients to the subproject directors, and will also coordinate the timing of data collection for the various subprojects. Finally, the Clinical Core will conduct an investigation to examine the impact of the development of chronic neuropathic pain on thermal and vibratory sensation in dermatomes adjacent to the injured region. This study will also examine the relationship between depression, somatic focus, cognitive distortions, and perceived intensity and unpleasantness of thermal stimulation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD033986-02
Application #
6241337
Study Section
Project Start
1997-08-01
Project End
1998-07-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Casey, Kenneth L; Geisser, Michael; Lorenz, Jürgen et al. (2012) Psychophysical and cerebral responses to heat stimulation in patients with central pain, painless central sensory loss, and in healthy persons. Pain 153:331-41
Paulson, Pamela E; Gorman, A L; Yezierski, Robert P et al. (2005) Differences in forebrain activation in two strains of rat at rest and after spinal cord injury. Exp Neurol 196:413-21
Hong, Shuangsong; Morrow, Thomas J; Paulson, Pamela E et al. (2004) Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat. J Biol Chem 279:29341-50
Casey, Kenneth L; Lorenz, Jurgen; Minoshima, Satoshi (2003) Insights into the pathophysiology of neuropathic pain through functional brain imaging. Exp Neurol 184 Suppl 1:S80-8
Lorenz, J; Minoshima, S; Casey, K L (2003) Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain 126:1079-91
Lorenz, Jurgen; Cross, Donna J; Minoshima, Satoshi et al. (2002) A unique representation of heat allodynia in the human brain. Neuron 35:383-93
Paulson, Pamela E; Casey, Kenneth L; Morrow, Thomas J (2002) Long-term changes in behavior and regional cerebral blood flow associated with painful peripheral mononeuropathy in the rat. Pain 95:31-40
Casey, K L; Morrow, T J; Lorenz, J et al. (2001) Temporal and spatial dynamics of human forebrain activity during heat pain: analysis by positron emission tomography. J Neurophysiol 85:951-9
Paulson, P E; Morrow, T J; Casey, K L (2000) Bilateral behavioral and regional cerebral blood flow changes during painful peripheral mononeuropathy in the rat. Pain 84:233-45
Casey, K L; Svensson, P; Morrow, T J et al. (2000) Selective opiate modulation of nociceptive processing in the human brain. J Neurophysiol 84:525-33

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