This is a competitive renewal application seeking funds to support a Program Project Grant at the Oregon Health & Science University. The Program is composed of five interwoven projects designed to test the umbrella hypothesis that stressors of the fetal cardiovascular and renal systems irreversibly alter early gene expression patterns and thereby predispose the offspring for disease in later life. Project by Woods will investigate the role of gender in determining susceptibility to hypertension after intrauterine protein deprivation. Project by Faber will study the role of prenatal of role of prenatal angiotensin II and hypertension in setting long-term blood presume in adults as well as renal and cardiac function. Project by Thornburg will investigate the relationship between cardiac myocyte and coronary vascular development and their long-term effects on disease susceptibility. Project by Baby will investigate the role of protein deprivation in determining long-term kidney function and regulation of the renin-angiotensin system. Project by Stork will investigate the role of the mitogen-activate protein kinase system as a regulator of cell proliferation and cell growth during the development. Core A is the administrative core that will oversee the administration of the program grant and provide coordination services. Core B is the animal core, headed by a senior veterinarian who oversee animal purchase and use and will provide overall cost savings. Core C is the imaging core and is headed by the director of OHSU Anatomic Pathology. It will provide immunochemistry histology and sophisticated microscopy services. This program has attracted a highly talented interdisciplinary faculty and the program is designed to integrated whole animal physiology cell culture, transgenic animals, and molecular biology to address problems of high-priority in the development of human disease.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD034430-10
Application #
7083666
Study Section
Special Emphasis Panel (ZHD1-MCHG-B (TK))
Program Officer
Ilekis, John V
Project Start
1997-06-01
Project End
2007-05-31
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
10
Fiscal Year
2006
Total Cost
$1,231,730
Indirect Cost
Name
Oregon Health and Science University
Department
Physiology
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Kolahi, Kevin S; Valent, Amy M; Thornburg, Kent L (2017) Cytotrophoblast, Not Syncytiotrophoblast, Dominates Glycolysis and Oxidative Phosphorylation in Human Term Placenta. Sci Rep 7:42941
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Barry, James S; Rozance, Paul J; Brown, Laura D et al. (2016) Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction. Exp Biol Med (Maywood) 241:839-47
Thornburg, Kent L; Kolahi, Kevin; Pierce, Melinda et al. (2016) Biological features of placental programming. Placenta 48 Suppl 1:S47-S53
Chadderdon, Scott M; Belcik, J Todd; Bader, Lindsay et al. (2016) Temporal Changes in Skeletal Muscle Capillary Responses and Endothelial-Derived Vasodilators in Obesity-Related Insulin Resistance. Diabetes 65:2249-57
Kolahi, Kevin; Louey, Samantha; Varlamov, Oleg et al. (2016) Real-Time Tracking of BODIPY-C12 Long-Chain Fatty Acid in Human Term Placenta Reveals Unique Lipid Dynamics in Cytotrophoblast Cells. PLoS One 11:e0153522
Jonker, Sonnet S; Davis, Lowell; Soman, Divya et al. (2016) Functional adaptations of the coronary microcirculation to anaemia in fetal sheep. J Physiol 594:6165-6174
Jonker, S S; Louey, S (2016) Endocrine and other physiologic modulators of perinatal cardiomyocyte endowment. J Endocrinol 228:R1-18

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