Abstract

The objectives of the Subject core are to: 1) recruit 200 rigorously diagnosed high functioning autistic subjects over the 5 year period of study, 2) recruit 200 individually matched normal controls who have a negative personal and family history of developmental and neuropsychiatric disorders, plus 10 additional normal controls of average IQ for the longitudinal study, 3) characterize autistic subjects in terms of the most likely clinical indicators of four separate genetic subgroups (family history of """"""""lesser variant"""""""" of autism, family history of mood disorder or anxiety disorder, regression as mode of autism onset, and elevated peripheral serotonin levels), 4) administer the neuropsychologic and cognitive psychology testing from Projects I and II, and 5) provide behavioral management and support for all subjects during fMRI and laboratory eye movement procedures in Projects II and III.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
1P01HD035469-02
Application #
6272424
Study Section
Project Start
1998-06-01
Project End
1999-05-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Mellon Pitts Corporation (Mpc Corp)
Department
Type
DUNS #
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Lynn, Andrew C; Padmanabhan, Aarthi; Simmonds, Daniel et al. (2018) Functional connectivity differences in autism during face and car recognition: underconnectivity and atypical age-related changes. Dev Sci 21:
Roemer, Emily J; West, Kelsey L; Northrup, Jessie B et al. (2018) Word comprehension mediates the link between gesture and word production: Examining language development in infant siblings of children with autism spectrum disorder. Dev Sci :e12767
Heymann, Perrine; Northrup, Jessie B; West, Kelsey L et al. (2018) Coordination is key: Joint attention and vocalisation in infant siblings of children with Autism Spectrum Disorder. Int J Lang Commun Disord 53:1007-1020
Iverson, Jana M; Northrup, Jessie B; Leezenbaum, Nina B et al. (2018) Early Gesture and Vocabulary Development in Infant Siblings of Children with Autism Spectrum Disorder. J Autism Dev Disord 48:55-71
West, Kelsey L; Leezenbaum, Nina B; Northrup, Jessie B et al. (2017) The Relation Between Walking and Language in Infant Siblings of Children With Autism Spectrum Disorder. Child Dev :
Haigh, Sarah M; Gupta, Akshat; Barb, Scott M et al. (2016) Differential sensory fMRI signatures in autism and schizophrenia: Analysis of amplitude and trial-to-trial variability. Schizophr Res 175:12-19
LeBarton, Eve Sauer; Iverson, Jana M (2016) Associations between gross motor and communicative development in at-risk infants. Infant Behav Dev 44:59-67
Focaroli, Valentina; Taffoni, Fabrizio; Parsons, Shelby M et al. (2016) Performance of Motor Sequences in Children at Heightened vs. Low Risk for ASD: A Longitudinal Study from 18 to 36 Months of Age. Front Psychol 7:724
O'Hearn, Kirsten; Velanova, Katerina; Lynn, Andrew et al. (2016) Abnormalities in brain systems supporting individuation and enumeration in autism. Autism Res 9:82-96
LeBarton, Eve Sauer; Iverson, Jana M (2016) Gesture development in toddlers with an older sibling with autism. Int J Lang Commun Disord 51:18-30

Showing the most recent 10 out of 47 publications