Abstract

The purpose of the project is to examine the short-term and long-term consequence of developmental exposure of oxytocin (OT). The time parameters, doses and specificity of OT will be examined, in experiments that will be used to define animal models for the more fine-grained analyses of Projects II-IV. Animals from this project will be used in Project IV in an analysis of cFos changes as an immediate result of treatment with OT during development. Basic functions, including patterns of growth, reproduction and basal endocrine parameters will be examined in rats and voles. The behaviors and endocrine measures to be studied are functions which have been shown to be sensitive to OT in adulthood. Among the behaviors to be measured are birth, maternal behavior and mating and natural estrus, along with pain thresholds. Among the endocrine parameters to be measured are steroid and peptide hormones (including OT and AVP). We also will examine the growth patterns of these animals and metabolic hormones including CCK, insulin, as well as glucose.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
7P01HD038490-02
Application #
6456647
Study Section
Special Emphasis Panel (ZHD1)
Project Start
2001-06-01
Project End
2002-02-28
Budget Start
Budget End
Support Year
2
Fiscal Year
2001
Total Cost
$129,677
Indirect Cost

  Institution

Name
University of Maryland College Park
Department
Type
DUNS #
City
College Park
State
MD
Country
United States
Zip Code
20742

  Publications

Kenkel, William M; Carter, C Sue (2016) Voluntary exercise facilitates pair-bonding in male prairie voles. Behav Brain Res 296:326-330
Kenkel, William M; Yee, Jason R; Porges, Stephen W et al. (2015) Cardioacceleration in alloparents in response to stimuli from prairie vole pups: the significance of thermoregulation. Behav Brain Res 286:71-9
Kenkel, William M; Suboc, Gessa; Carter, C Sue (2014) Autonomic, behavioral and neuroendocrine correlates of paternal behavior in male prairie voles. Physiol Behav 128:252-9
Kenkel, William M; Paredes, Jamespaul; Lewis, Gregory F et al. (2013) Autonomic substrates of the response to pups in male prairie voles. PLoS One 8:e69965
Pournajafi-Nazarloo, Hossein; Partoo, Leila; Yee, Jason et al. (2011) Effects of social isolation on mRNA expression for corticotrophin-releasing hormone receptors in prairie voles. Psychoneuroendocrinology 36:780-9
Pournajafi-Nazarloo, Hossein; Partoo, Leila; Sanzenbacher, Lisa et al. (2009) Stress differentially modulates mRNA expression for corticotrophin-releasing hormone receptors in hypothalamus, hippocampus and pituitary of prairie voles. Neuropeptides 43:113-23
White-Traut, Rosemary; Watanabe, Kaoru; Pournajafi-Nazarloo, Hossein et al. (2009) Detection of salivary oxytocin levels in lactating women. Dev Psychobiol 51:367-73
Perry, Adam N; Paramadilok, Auratip; Cushing, Bruce S (2009) Neonatal oxytocin alters subsequent estrogen receptor alpha protein expression and estrogen sensitivity in the female rat. Behav Brain Res 205:154-61
Carter, C Sue; Boone, Ericka M; Pournajafi-Nazarloo, Hossein et al. (2009) Consequences of early experiences and exposure to oxytocin and vasopressin are sexually dimorphic. Dev Neurosci 31:332-41
Pournajafi-Nazarloo, Hossein; Partoo, Leila; Sanzenbacher, Lisa et al. (2009) Social isolation modulates corticotropin-releasing factor type 2 receptor, urocortin 1 and urocortin 2 mRNAs expression in the cardiovascular system of prairie voles. Peptides 30:940-6

Showing the most recent 10 out of 53 publications